我们对人类生殖系基因组编辑究竟是怎么想的，它对医学又意味着什么？
What Do We Really Think About Human Germline Genome Editing, and What Does It Mean for Medicine?
作者信息
Musunuru Kiran, Lagor William R, Miano Joseph M
机构信息
From the Cardiovascular Institute, Department of Medicine, and Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (K.M.); Department of Molecular Physiology and Biophysics, Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX (W.R.L.); and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (J.M.M.).
出版信息
Circ Cardiovasc Genet. 2017 Oct;10(5). doi: 10.1161/CIRCGENETICS.117.001910.
Genome editing has captured widespread attention due to its potential therapeutic applications. Early studies with human embryos have established the feasibility of human germline genome editing but raise complex social, ethical, and legal questions. In light of the potential impact of genome editing on the practice of cardiovascular medicine, we surveyed ≈300 attendees at a recent American Heart Association conference to elicit their opinions on somatic and germline genome editing. The results were revealing and highlight the need to broadly engage the public and solicit the opinions of various constituencies before proceeding with clinical germline genome editing.
基因组编辑因其潜在的治疗应用而受到广泛关注。早期对人类胚胎的研究证实了人类生殖系基因组编辑的可行性，但也引发了复杂的社会、伦理和法律问题。鉴于基因组编辑对心血管医学实践的潜在影响，我们在最近一次美国心脏协会会议上对约300名与会者进行了调查，以了解他们对体细胞和生殖系基因组编辑的看法。结果发人深省，凸显了在进行临床生殖系基因组编辑之前，需要广泛地让公众参与并征求各方面的意见。
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