治疗性种系编辑：有识之士的观点。

Therapeutic Germline Editing: Sense and Sensibility.

机构信息

Warren Alpert Medical School, Brown University, Providence, RI, USA.

Harvard Law School, Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard University, Cambridge, MA, USA.

出版信息

Trends Genet. 2020 May;36(5):315-317. doi: 10.1016/j.tig.2019.12.011. Epub 2020 Jan 22.

DOI:10.1016/j.tig.2019.12.011

PMID:31982142

Abstract

Safe and effective heritable editing of the human genome is years away from the clinic because of formidable technical, statutory, regulatory, and societal challenges. In particular, we note the fledgling state of the science, the imperatives of editing efficiency, specificity, and uniformity, and the extant legal roadblock.

摘要

安全有效的人类基因组可遗传编辑技术距离临床应用还有数年时间，因为面临着严峻的技术、法规、监管和社会挑战。特别是，我们注意到该科学尚处于起步阶段，编辑效率、特异性和一致性的必要性，以及现存的法律障碍。