Ishii F, Takamura A, Ogata H
Meiji College of Pharmacy, Tokyo, Japan.
J Pharm Pharmacol. 1988 Feb;40(2):89-92. doi: 10.1111/j.2042-7158.1988.tb05187.x.
Three prodrugs, N-alpha-acetyl-L-arginine, N-alpha-acetyl-L-histidine and N-alpha-acetyl-L-lysine have been examined to see if they could induce significant changes in the stability of an intravenous fat emulsion, the stability being evaluated in terms of physicochemical measurements such as particle size distribution, surface tension, pH and zeta potential. The acetyl amino acids had an excellent stabilizing effect on the emulsion compared with amino acids without acetyl groups.
已经对三种前药，即N-α-乙酰基-L-精氨酸、N-α-乙酰基-L-组氨酸和N-α-乙酰基-L-赖氨酸进行了研究，以考察它们是否会引起静脉脂肪乳剂稳定性的显著变化，该稳定性通过粒度分布、表面张力、pH值和ζ电位等物理化学测量来评估。与没有乙酰基的氨基酸相比，乙酰化氨基酸对乳剂具有出色的稳定作用。
