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本文引用的文献

1
Status epilepticus of inflammatory etiology: a cohort study.炎症性病因所致癫痫持续状态:一项队列研究
Neurology. 2015 Aug 4;85(5):464-70. doi: 10.1212/WNL.0000000000001717. Epub 2015 Jun 19.
2
Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study.抗 NMDA 受体脑炎患者的长期预后的治疗和预后因素:一项观察性队列研究。
Lancet Neurol. 2013 Feb;12(2):157-65. doi: 10.1016/S1474-4422(12)70310-1. Epub 2013 Jan 3.
3
Autoimmune encephalitis: a case series and comprehensive review of the literature.自身免疫性脑炎:病例系列及文献综述
QJM. 2011 Nov;104(11):921-31. doi: 10.1093/qjmed/hcr111. Epub 2011 Jul 22.
4
Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies.抗N-甲基-D-天冬氨酸受体脑炎:病例系列及抗体作用分析
Lancet Neurol. 2008 Dec;7(12):1091-8. doi: 10.1016/S1474-4422(08)70224-2. Epub 2008 Oct 11.
5
Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.与卵巢畸胎瘤相关的副肿瘤性抗N-甲基-D-天冬氨酸受体脑炎
Ann Neurol. 2007 Jan;61(1):25-36. doi: 10.1002/ana.21050.

一位年轻女士中抗 NMDA 受体脑炎致难治性癫痫持续状态的不寻常病例

An unusual case of refractory status epilepticus in a young lady: anti-NMDA receptor encephalitis.

机构信息

Pusat Perubatan Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia

Hospital Ampang, Selangor, Malaysia.

出版信息

Clin Med (Lond). 2017 Oct;17(5):436-438. doi: 10.7861/clinmedicine.17-5-436.

DOI:10.7861/clinmedicine.17-5-436
PMID:28974594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6301918/
Abstract

We describe a case of a young lady with anti-NMDA (N-methyl-D-aspartate) receptor encephalitis, who initially presented with status epilepticus. Her seizures and orofacial dyskinesia were refractory to four anticonvulsants. She received intravenous immunoglobulin and a left ovarian tumour (an associated feature) was resected. However, her outcome was poor because of delayed treatment, autonomic dysfunction and complications of prolonged hospitalisation. This case highlights the importance of an early recognition of this rare but increasingly recognised disease.

摘要

我们描述了一例抗 NMDA(N-甲基-D-天冬氨酸)受体脑炎的年轻女性患者,她最初表现为癫痫持续状态。她的癫痫发作和口面运动障碍对四种抗癫痫药物均无反应。她接受了静脉注射免疫球蛋白和左卵巢肿瘤(一种相关特征)切除术。然而,由于治疗延迟、自主神经功能障碍和长期住院并发症,她的预后不佳。这个病例强调了早期识别这种罕见但越来越被认识的疾病的重要性。