初潮年龄与早产患病率：来自健康婴儿队列研究的结果。
Age at menarche and prevalence of preterm birth: Results from the Healthy Baby Cohort study.
机构信息
Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
出版信息
Sci Rep. 2017 Oct 3;7(1):12594. doi: 10.1038/s41598-017-12817-2.
Little is known about the impact of age at menarche on preterm birth. The aim of this study was to examine the association between age at menarche and preterm birth. A total of 11,016 Chinese women who gave birth to live singleton infants were recruited from the Healthy Baby Cohort between 2012 and 2014 in the province of Hubei, China. Age at menarche was reported via face-to-face interviews and was categorized into five groups (≤11, 12, 13, 14 and ≥15 years). Gestational age was estimated using maternal last menstrual period. Preterm birth was defined as delivering a live singleton infant at <37 weeks' gestational age. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Earlier menarche (≤11 years) was associated with an increased prevalence of preterm birth (OR: 1.67, 95% CI: 1.18, 2.36) compared with menarche age at 13 years after controlling for the potential confounders. The findings of our study suggested that a history of earlier menarche might be useful for identifying women at higher risk of preterm birth.
关于初潮年龄对早产的影响知之甚少。本研究旨在探讨初潮年龄与早产之间的关系。这项研究共纳入了 11016 名 2012 年至 2014 年期间在中国湖北省出生的单胎活产婴儿的中国妇女。通过面对面访谈报告初潮年龄，并将其分为五组（≤11 岁、12 岁、13 岁、14 岁和≥15 岁）。通过母亲的最后一次月经来估计胎龄。早产的定义是在 37 周胎龄之前分娩出单胎活婴。使用 logistic 回归来估计比值比（OR）和 95%置信区间（CI）。与 13 岁初潮相比，初潮年龄较早（≤11 岁）与早产的发生率增加相关（OR：1.67，95%CI：1.18，2.36），调整了潜在混杂因素后。本研究的结果表明，初潮较早的病史可能有助于识别早产风险较高的女性。
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