Department of Anatomy and Comparative Pathology, University of Murcia, Campus Espinardo, 30100 Murcia, Spain.
Minimally Invasive Surgery Centre Jesús Usón, 10071 Cáceres, Spain.
World J Gastroenterol. 2017 Sep 14;23(34):6201-6211. doi: 10.3748/wjg.v23.i34.6201.
Double balloon enteroscopy (DBE) is an endoscopic technique broadly used to diagnose and treat small bowel diseases. Among the associated complications of the oral DBE, post-procedure pancreatitis has taken the most attention due to its gravity and the thought that it might be associated to the technique itself and anatomical features of the pancreas. However, as the etiology has not been clarified yet, this paper aims to review the published literature and adds new results from a porcine animal model. Biochemical markers, histological sections and the vascular perfusion of the pancreas were monitored in the pig during DBE practice. A reduced perfusion of the pancreas and bowel, the presence of defined hypoxic areas and disseminated necrotic zones were found in the pancreatic tissue of pigs. All these evidences contribute to support a vascular distress as the most likely etiology of the post-DBE pancreatitis.
双气囊小肠镜（DBE）是一种广泛用于诊断和治疗小肠疾病的内镜技术。在口服 DBE 相关的并发症中，由于其严重性以及认为其可能与技术本身和胰腺的解剖特征有关，因此胰腺炎引起了最多的关注。然而，由于病因尚未明确，本文旨在综述已发表的文献，并从猪的动物模型中添加新的结果。在 DBE 实践过程中，监测猪的胰腺的生化标志物、组织切片和血管灌注。在猪的胰腺组织中发现了胰腺和肠道的灌注减少，存在明确的缺氧区域和弥散性坏死区。所有这些证据都支持血管窘迫是 DBE 后胰腺炎的最可能病因。
