Department of Endoscopy, Minimally Invasive Surgery Centre, Carretera N-521, Caceres, Spain.
Dig Endosc. 2013 Jan;25(1):39-46. doi: 10.1111/j.1443-1661.2012.01320.x. Epub 2012 Apr 26.
The aim of the present study was to assess the safety and efficacy of CO(2) during double-balloon enteroscopy (DBE) in an experimental animal model study. In this study, insufflation with room air and with CO(2) was compared.
Twenty healthy swines were used. The animals were randomly allocated to two groups. The room air-DBE group was insufflated with room air, whereas the CO(2)-DBE group was insufflated with CO(2). Endoscopy duration was 90 min. The following parameters were measured during the study (basal, 30 min, 60 min, 90 min): invasive hemodynamic parameters, ventilatory parameters, arterial blood gases, exploration depth, as well as biochemical tests. Residual gas was evaluated at the end of DBE, at 180 min and 24 h after DBE.
During the endoscopic exploration none of the animals showed hemodynamic, ventilatory or arterial blood gas alterations in the normal reference range for the swine species. The CO(2) group showed statistically significant differences over the room air group with lower post-procedure residual gas and greater depth of the small bowel explored.
The use of CO(2) for insufflation during DBE was safe and no complications associated with CO(2) were observed. In addition, the use of CO(2) offers benefits over the use of room air for insufflation during DBE.
本研究旨在评估 CO₂ 在双气囊内镜检查（DBE）中的安全性和有效性，这是一项在实验动物模型中的研究。在本研究中，比较了使用空气和 CO₂ 进行充气。
20 头健康的猪被用于本研究。这些动物被随机分配到两组。空气-DBE 组使用空气进行充气，而 CO₂-DBE 组使用 CO₂ 进行充气。内镜检查持续 90 分钟。在研究过程中（基础状态、30 分钟、60 分钟、90 分钟）测量以下参数：有创血流动力学参数、通气参数、动脉血气、探查深度以及生化测试。在 DBE 结束时、DBE 后 180 分钟和 24 小时评估残余气体。
在整个内镜检查过程中，没有动物出现超出猪种正常参考范围的血流动力学、通气或动脉血气改变。CO₂ 组与空气组相比，术后残余气体统计学上显著减少，并且小肠探查深度更大。
在 DBE 中使用 CO₂ 进行充气是安全的，并且没有观察到与 CO₂ 相关的并发症。此外，与使用空气充气相比，CO₂ 为 DBE 充气提供了更多益处。
