特发性节段性肌张力障碍长期苍白球刺激后运动亢进的发生
Development of Hyperkinesias after Long-term Pallidal Stimulation for Idiopathic Segmental Dystonia.
作者信息
Wloch Andreas, Blahak Christian, Abdallat Mahmoud, Heissler Hans E, Wolf Marc E, Krauss Joachim K
机构信息
Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
Department of Neurology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2017 Sep 19;7:480. doi: 10.7916/D8V416KN. eCollection 2017.
BACKGROUND
Chronic deep brain stimulation (DBS) of the globus pallidus internus (GPi) has become an established treatment for dystonia. While bradykinetic symptoms may occur on chronic stimulation, the appearance of hyperkinetic movements has not been well characterized.
CASE REPORT
We report on the development of hyperkinesias after more than 10 years of GPi DBS.
DISCUSSION
Hyperkinesias may evolve upon long-term GPi DBS in dystonia. This might be related to a combined effect consisting of a reduced threshold for effective GPi stimulation for dystonia and spread of current to the globus pallidus externus.
背景
内侧苍白球（GPi）的慢性深部脑刺激（DBS）已成为治疗肌张力障碍的既定方法。虽然慢性刺激时可能会出现运动迟缓症状，但运动亢进性运动的出现尚未得到充分描述。
病例报告
我们报告了在进行GPi DBS超过10年后出现运动亢进的情况。
讨论
肌张力障碍患者长期进行GPi DBS可能会出现运动亢进。这可能与以下综合效应有关：肌张力障碍有效GPi刺激的阈值降低，以及电流扩散至外侧苍白球。
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