Wright David, Hoang Melinda, Sofine Anna, Silva Jack P, Schwarzkopf Ran
School of Medicine, University of California, Irvine, Irvine, CA, USA.
Division of Adult Reconstruction, Department of Orthopaedic Surgery, NYU Langone Medical Center, NYU Hospital for Joint Diseases, 310 East 17th Street, New York, NY, 10003, USA.
Arch Orthop Trauma Surg. 2017 Dec;137(12):1623-1629. doi: 10.1007/s00402-017-2812-x. Epub 2017 Oct 3.
Pain catastrophizing has been suggested as a prospective risk factor for poor postoperative pain outcomes in total joint arthroplasty (TJA). However, results from the previous studies have been mixed and have not controlled for postoperative opiate analgesic intake. This study investigates pain catastrophizing and postoperative pain intensity in TJA patients, adjusting for analgesic intake. We hypothesized that "pain catastrophizers" would exhibit higher pain scores and increased analgesic requirements postoperatively.
In this prospective cohort study, patients were defined as catastrophizers (PCS > 30), or non-catastrophizers (PCS ≤ 30). The primary outcome was the visual analog scale (VAS) pain score at 3-month follow-up. Secondary outcomes included length of stay (LOS) for the index hospitalization, total daily opiate analgesic intake, and VAS pain scores on postoperative days 0, 1, 2, and 3 through discharge. Multivariable regression was used to control for total daily morphine equivalent dose consumed during the stay in addition to other clinical and demographic factors.
There were 87 patients in the "non-catastrophizing" and 36 in the "catastrophizing" groups. There was no clinically significant difference in VAS pain scores between groups at 3-month follow-up. Patients with a length of stay (LOS) ≥ 3 postoperative days differed in VAS pain scores ("non-catastrophizers" = 5.08 vs. "catastrophizers" = 7.13; p = 0.002) and were 2.4 times more likely to be catastrophizers than non-catastrophizers (p = 0.042). There were no differences in the remaining secondary outcomes.
The pain catastrophizing scale is a poor predictor of postoperative pain at 3-month follow-up. However, it may be a risk factor for increased LOS.
疼痛灾难化被认为是全关节置换术(TJA)术后疼痛效果不佳的一个潜在风险因素。然而,先前研究的结果并不一致,且未对术后阿片类镇痛药的摄入量进行控制。本研究对TJA患者的疼痛灾难化和术后疼痛强度进行了调查,并对镇痛药摄入量进行了调整。我们假设“疼痛灾难化者”术后会表现出更高的疼痛评分和更多的镇痛药需求。
在这项前瞻性队列研究中,患者被定义为灾难化者(PCS>30)或非灾难化者(PCS≤30)。主要结局是3个月随访时的视觉模拟量表(VAS)疼痛评分。次要结局包括首次住院的住院时间(LOS)、每日阿片类镇痛药总摄入量,以及术后第0、1、2和3天直至出院时的VAS疼痛评分。除其他临床和人口统计学因素外,多变量回归用于控制住院期间每日吗啡等效剂量的总量。
“非灾难化”组有87例患者,“灾难化”组有36例患者。3个月随访时,两组间VAS疼痛评分无临床显著差异。术后住院天数≥3天的患者在VAS疼痛评分上存在差异(“非灾难化者”=5.08,“灾难化者”=7.13;p=0.002),且“灾难化者”成为灾难化者的可能性是非灾难化者的2.4倍(p=0.042)。其余次要结局无差异。
疼痛灾难化量表在3个月随访时对术后疼痛的预测能力较差。然而,它可能是住院时间延长的一个风险因素。