英格兰和威尔士的运动神经元疾病与既往脊髓灰质炎病史

Motoneuron disease and past poliomyelitis in England and Wales.

作者信息

Martyn C N, Barker D J, Osmond C

机构信息

MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital.

出版信息

Lancet. 1988 Jun 11;1(8598):1319-22. doi: 10.1016/s0140-6736(88)92129-0.

DOI:10.1016/s0140-6736(88)92129-0

PMID:2897566

Abstract

Past notification rates for poliomyelitis show a close geographical relation with current mortality from motoneuron disease in England and Wales. The increasing rate of poliomyelitis during the first half of this century and its predilection for affluent places and families were unique amongst infectious diseases. The unusual epidemiology of poliomyelitis is now being paralleled by motoneuron disease. These observations provide new evidence for a causal connection between the two conditions.

摘要

过去脊髓灰质炎的报告发病率与英格兰和威尔士目前运动神经元病的死亡率呈现出密切的地理关联。在本世纪上半叶，脊髓灰质炎发病率的上升及其在富裕地区和家庭中的高发，在传染病中是独一无二的。如今运动神经元病呈现出与脊髓灰质炎不同寻常的流行病学特征相似的情况。这些观察结果为这两种病症之间的因果联系提供了新证据。