Kis Bela, El-Haddad Ghassan, Sheth Rahul A, Parikh Nainesh S, Ganguli Suvranu, Shyn Paul B, Choi Junsung, Brown Karen T
1 Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
2 Department of Interventional Radiology, MD Anderson Cancer Center, Houston, TX, USA.
Cancer Control. 2017 Jul-Sep;24(3):1073274817729244. doi: 10.1177/1073274817729244.
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC) are primary liver cancers where all or most of the tumor burden is usually confined to the liver. Therefore, locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease with minimal systemic side effects. The English medical literature and clinical trials were reviewed to provide a synopsis on the available liver-directed percutaneous therapies for HCC and IHC. Locoregional liver-directed therapies provide survival benefit for patients with HCC and IHC compared to best medical treatment and have lower comorbid risks compared to surgical resection. These treatment options should be considered, especially in patients with unresectable disease.
肝细胞癌(HCC)和肝内胆管癌(IHC)是原发性肝癌,其全部或大部分肿瘤负荷通常局限于肝脏。因此,局部肝脏定向治疗能够提供一个以最小的全身副作用来控制肝内疾病的机会。我们回顾了英文医学文献和临床试验,以概述针对HCC和IHC的现有经皮肝脏定向治疗方法。与最佳药物治疗相比,局部肝脏定向治疗可为HCC和IHC患者带来生存获益,且与手术切除相比,其合并症风险更低。应考虑这些治疗选择,尤其是对于不可切除疾病的患者。