Department of Laboratory Medicine, Brain Hospital, Siping, Jilin Province, China.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(17):3911-3915.
We investigated the relationship between the serum macrophage chemokine ligand 16 (CXCL16) levels and the vulnerable carotid plaque in patients with ischemic stroke.
We successively selected 118 cases of patients with an initial diagnosis of acute ischemic stroke (time of onset < 72 h), recorded risk factors, including gender, age, family history, smoking, body mass index, blood glucose levels, blood lipid levels, average systolic pressure and diastolic blood pressure (DBP) and homocysteine levels. ELISA was used to detect the levels of serum CXCL16. GE-3000 color Doppler ultrasound diagnostic instrument was applied for the detection of the cervical artery (including a bilateral common carotid artery, internal carotid artery and external carotid artery) intima-media thickness (IMT), plaque number, size, nature (stable and vulnerable) and luminal stenosis rate. Delica EMS-9EBx2P type transcranial Doppler ultrasound (TCD) was used to detect micro-arterial micro-embolic signals (MES). Stroke, according to etiologic type, was divided into large artery atherosclerosis (LAA), small artery occlusion (SAA) and others.
Serum CXCL16 levels were not significantly correlated with sex, age, family history, smoking, BMI, blood glucose levels, blood lipid levels, mean systolic blood pressure, diastolic blood pressure, and homocysteine levels. Serum CXCL16 levels increased with an increase of IMT, plaque area and lumen stenosis rate. Serum CXCL16 levels of vulnerable plaques were significantly higher than those of stable plaques; differences were statistically significant (p<0.05). It has nothing to do with the number of atherosclerotic plaques. The levels of serum CXCL16 in MES positive group were significantly higher than that in MES negative group; differences were statistically significant (p<0.05). The serum CXCL16 levels of LAA patients were significantly higher than that of SAA and other types of patients; differences were statistically significant (p<0.05).
The levels of serum CXCL16 are not related to high-risk factors for acute stroke and closely related to characteristics of atherosclerotic plaque, micro-embolic signals and stroke subtypes.
研究血清巨噬细胞趋化因子配体 16（CXCL16）水平与缺血性脑卒中患者易损颈动脉斑块之间的关系。
连续选择 118 例初诊为急性缺血性脑卒中（发病时间＜72 h）患者，记录性别、年龄、家族史、吸烟、体重指数、血糖、血脂、平均收缩压和舒张压（DBP）及同型半胱氨酸水平等危险因素，采用酶联免疫吸附试验（ELISA）检测血清 CXCL16 水平，应用 GE-3000 彩色多普勒超声诊断仪检测颈总动脉（包括双侧颈内、颈外动脉）内-中膜厚度（IMT）、斑块数量、大小、性质（稳定型和易损型）及管腔狭窄率，采用 Delica EMS-9EBx2P 型经颅多普勒超声（TCD）检测微动脉微栓子信号（MES）。根据病因学分型，脑卒中分为大动脉粥样硬化型（LAA）、小动脉闭塞型（SAA）及其他型。
血清 CXCL16 水平与性别、年龄、家族史、吸烟、BMI、血糖、血脂、平均收缩压、DBP 及同型半胱氨酸水平无明显相关性，与 IMT、斑块面积及管腔狭窄率呈正相关。易损斑块组血清 CXCL16 水平明显高于稳定斑块组，差异有统计学意义（p＜0.05），与斑块数量无关；MES 阳性组血清 CXCL16 水平明显高于 MES 阴性组，差异有统计学意义（p＜0.05）；LAA 患者血清 CXCL16 水平明显高于 SAA 及其他类型患者，差异有统计学意义（p＜0.05）。
血清 CXCL16 水平与急性脑卒中的高危因素无关，与动脉粥样硬化斑块特征、微栓子信号及脑卒中亚型密切相关。
