Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.
School of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Cells. 2020 Nov 10;9(11):2453. doi: 10.3390/cells9112453.
The process of atherosclerosis leads to the formation of plaques in the arterial wall, resulting in a decreased blood supply to tissues and organs and its sequelae: morbidity and mortality. A class of membrane-bound proteins termed scavenger receptors (SRs) are closely linked to the initiation and progression of atherosclerosis. Increasing interest in understanding SR structure and function has led to the idea that these proteins could provide new routes for cardiovascular disease diagnosis, management, and treatment. In this review, we consider the main classes of SRs that are implicated in arterial disease. We consider how our understanding of SR-mediated recognition of diverse ligands, including modified lipid particles, lipids, and carbohydrates, has enabled us to better target SR-linked functionality in disease. We also link clinical studies on vascular disease to our current understanding of SR biology and highlight potential areas that are relevant to cardiovascular disease management and therapy.
动脉粥样硬化的形成过程导致动脉壁斑块的形成，从而导致组织和器官的血液供应减少及其后果：发病率和死亡率。一类称为清道夫受体（SRs）的膜结合蛋白与动脉粥样硬化的发生和发展密切相关。越来越多的人对理解 SR 结构和功能的兴趣使得这些蛋白质可以为心血管疾病的诊断、管理和治疗提供新的途径。在这篇综述中，我们考虑了与动脉疾病相关的主要 SR 类。我们考虑了我们对 SR 介导的对不同配体（包括修饰的脂质颗粒、脂质和碳水化合物）的识别的理解如何使我们能够更好地针对疾病中的 SR 相关功能。我们还将血管疾病的临床研究与我们目前对 SR 生物学的理解联系起来，并强调与心血管疾病管理和治疗相关的潜在领域。
