Department of Orthopedics, Changzhou 2nd People's Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province, China.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(17):3900-3905.
To investigate the correlation of type 2 diabetes mellitus (DM) complicated with osteoporosis with lipid metabolism, adipokines and inflammatory factors, and to define the risk factors via the multivariate regression analysis.
A total of 80 patients with DM admitted into our hospital from November 2015 to November 2016 were enrolled, including 40 patients complicated with osteoporosis and 40 patients not complicated with osteoporosis. The levels of blood lipid, adipokines and inflammatory factors were compared; the correlations between bone mineral density (BMD) and total cholesterol (TC), adiponectin and tumor necrosis factor-α (TNF-α) were analyzed; and multivariate Logistic regression analysis was performed for osteoporosis, hyperlipidemia, abnormal adipokine levels and body's inflammatory response.
The levels of serum lipid indexes, total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C), in patients without complicating osteoporosis were significantly lower than those in patients complicated with osteoporosis. The level of high-density lipoprotein cholesterol (HDL-C) was significantly higher than that in patients complicated with osteoporosis. The levels of adipokines, adiponectin and visfatin, in patients without complicating osteoporosis were significantly lower than those in patients complicated with osteoporosis. The levels of inflammatory factors, TNF-α, interleukin-6 (IL-6) and C-reactive protein (CRP), in patients without complicating osteoporosis were significantly lower than those in patients complicated with osteoporosis. There were negative correlations between BMD and TC, adiponectin and TNF-α. Abnormal blood lipid, abnormal adipokine levels and elevated inflammatory factor levels were independent risk factors for osteoporosis.
Enhanced inflammatory response, abnormal blood lipid metabolism and abnormal changes in adipokines may increase the risk of osteoporosis in patients with diabetes mellitus.
探讨 2 型糖尿病（DM）合并骨质疏松症与脂代谢、脂肪因子和炎症因子的相关性，并通过多元回归分析确定其危险因素。
选取 2015 年 11 月至 2016 年 11 月我院收治的 80 例 DM 患者，包括合并骨质疏松症的 40 例和未合并骨质疏松症的 40 例。比较两组患者的血脂水平、脂肪因子和炎症因子水平；分析骨密度（BMD）与总胆固醇（TC）、脂联素和肿瘤坏死因子-α（TNF-α）的相关性；并对骨质疏松症、血脂异常、脂肪因子水平异常和机体炎症反应进行多元 Logistic 回归分析。
无骨质疏松症合并症患者的血清脂质指标总胆固醇（TC）、三酰甘油（TG）和低密度脂蛋白胆固醇（LDL-C）水平明显低于合并骨质疏松症患者，高密度脂蛋白胆固醇（HDL-C）水平明显高于合并骨质疏松症患者。无骨质疏松症合并症患者的脂肪因子脂联素和内脂素水平明显低于合并骨质疏松症患者。无骨质疏松症合并症患者的炎症因子 TNF-α、白细胞介素-6（IL-6）和 C 反应蛋白（CRP）水平明显低于合并骨质疏松症患者。BMD 与 TC、脂联素和 TNF-α呈负相关。血脂异常、脂肪因子水平异常和炎症因子水平升高是骨质疏松症的独立危险因素。
增强的炎症反应、异常的脂代谢和脂肪因子的异常变化可能会增加糖尿病患者发生骨质疏松症的风险。
