Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China.
BMC Musculoskelet Disord. 2024 Feb 20;25(1):162. doi: 10.1186/s12891-024-07284-6.
We aimed to explore the relationship between bone mineral density (BMD), bone metabolism markers, and blood lipid-related indicators, body mass index (BMI) in elderly individuals.
A retrospective analysis was conducted on 710 patients. Patients' gender, age, height, weight, bone density values, T-scores, bone metabolism markers (including serum N-terminal propeptide of type I collagen (s-PINP), serum C-terminal telopeptide of type I collagen (s-CTX) and 1,25-dihydroxyvitamin D (1,25(OH)D) and lipid-related indicators (including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and Castelli index 1 (TC/HDL-C index) and Castelli index 2 (LDL-C/HDL-C index) were recorded. Correlations between variables were analyzed, and patients were grouped according to gender and T-score for intergroup comparisons.
HDL-C negatively correlates with BMD and s-CTX. TG, Castelli index, and BMI positively correlate with BMD. BMI negatively correlates with s-PINP. 1,25(OH)D negatively correlates with TC, LDL-C, and Castelli index. LDL-C positively correlates with BMD in males, and TC negatively correlates with s-PINP. In females, HDL-C negatively correlates with BMD, and s-CTX positively correlates with Castelli index. 1,25(OH)D negatively correlates with TC, LDL-C, and Castelli index. TG and Castelli index were higher in normal bone mass group, while HDL-C is higher in the osteoporosis group. TG and BMI positively predicted bone mass density, while HDL-C negatively predicted bone mass density.
HDL-C may have a predictive role in osteoporosis, particularly in women. The likelihood of osteoporosis is lower in individuals with high BMI or hyperlipidemia. Some lipid metabolism markers can be used to predict osteoporosis, and further research is needed.
本研究旨在探讨老年人骨密度（BMD）、骨代谢标志物和血脂相关指标与体重指数（BMI）之间的关系。
对 710 例患者进行回顾性分析。记录患者的性别、年龄、身高、体重、骨密度值、T 评分、骨代谢标志物（包括血清 I 型胶原 N 端前肽（s-PINP）、血清 I 型胶原 C 端肽（s-CTX）和 1,25-二羟维生素 D（1,25（OH）D））和血脂相关指标（包括总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）和 Castelli 指数 1（TC/HDL-C 指数）和 Castelli 指数 2（LDL-C/HDL-C 指数））。分析变量之间的相关性，并根据性别和 T 评分对患者进行分组，进行组间比较。
HDL-C 与 BMD 和 s-CTX 呈负相关。TG、Castelli 指数和 BMI 与 BMD 呈正相关。BMI 与 s-PINP 呈负相关。1,25（OH）D 与 TC、LDL-C 和 Castelli 指数呈负相关。LDL-C 与男性的 BMD 呈正相关，而 TC 与 s-PINP 呈负相关。在女性中，HDL-C 与 BMD 呈负相关，s-CTX 与 Castelli 指数呈正相关。1,25（OH）D 与 TC、LDL-C 和 Castelli 指数呈负相关。TG 和 Castelli 指数在正常骨量组中较高，而 HDL-C 在骨质疏松组中较高。TG 和 BMI 正向预测骨密度，而 HDL-C 负向预测骨密度。
HDL-C 可能对骨质疏松症具有预测作用，尤其是在女性中。BMI 较高或血脂异常的个体发生骨质疏松症的可能性较低。一些血脂代谢标志物可用于预测骨质疏松症，需要进一步研究。
