Thampatty Bhavani P, Wang James H-C
MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 210 Lothrop street, BST, E1640, Pittsburgh, 15213, Pennsylvania.
J Orthop Res. 2018 Feb;36(2):557-565. doi: 10.1002/jor.23761. Epub 2017 Nov 22.
Tendons are unique in the sense that they are constantly subjected to large mechanical loads and that they contain tendon-specific cells, including tenocytes and tendon stem/progenitor cells. The responses of these cells to mechanical loads can be anabolic or catabolic and as a result, change the biological properties of the tendon itself that may be beneficial or detrimental. On the other hand, aging also induces aberrant changes in cellular expression of various genes and production of various types of matrix proteins in the tendon, and consequently lead to tendon degeneration and impaired healing in aging tendons; both could be improved by moderate physiological mechanical loading such as treadmill running. This article gives an overview on the mechanobiology research of young and aging animal tendons using treadmill running model. The challenges in such treadmill running studies are also discussed. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:557-565, 2018.
肌腱具有独特性，因为它们不断承受着巨大的机械负荷，并且包含肌腱特异性细胞，包括腱细胞和肌腱干/祖细胞。这些细胞对机械负荷的反应可能是合成代谢的，也可能是分解代谢的，结果会改变肌腱本身的生物学特性，这可能是有益的，也可能是有害的。另一方面，衰老还会导致肌腱中各种基因的细胞表达和各种类型基质蛋白的产生出现异常变化，从而导致肌腱退变以及衰老肌腱的愈合受损；而适度的生理机械负荷，如跑步机跑步，可能改善这两种情况。本文概述了使用跑步机跑步模型对年轻和衰老动物肌腱进行的力学生物学研究。还讨论了此类跑步机跑步研究中的挑战。© 2017 骨科研究协会。由威利期刊公司出版。《矫形外科研究杂志》36:557 - 565，2018年。
