Kitamura Tsuneo, Watanabe Sumio, Sato Nobuhiro
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
J Gastroenterol Hepatol. 1998 Sep;13(S1):S96-S99. doi: 10.1111/jgh.1998.13.s1.96.
Accumulating evidence has revealed that malignant cell growth is regulated by complex mechanisms involved in genetic and epigenetic factors. Among human cancers, cancer in the liver (hepatocellular carcinoma (HCC)) is characterized by the evidence that it is usually based on chronic liver diseases such as liver cirrhosis or chronic hepatitis, in which the liver is persistently regenerating following hepatic injury. This raises the possibility that repeated hepatocyte proliferation may cause disorder of genes that are regulating the cell cycle in hepatocytes, thus causing HCC. In this article, recent studies focusing on liver regeneration and cancer are reviewed from the viewpoint of the cell cycle that is regulated by cyclin and the associated proteins.
越来越多的证据表明，恶性细胞的生长受遗传和表观遗传因素等复杂机制的调控。在人类癌症中，肝癌（肝细胞癌，HCC）的特点是，它通常基于肝硬化或慢性肝炎等慢性肝病，在这些疾病中，肝脏在肝损伤后持续再生。这就增加了一种可能性，即反复的肝细胞增殖可能导致调节肝细胞细胞周期的基因紊乱，从而引发肝癌。在本文中，我们从由细胞周期蛋白和相关蛋白调控的细胞周期角度，综述了近期关于肝脏再生和癌症的研究。
