Department of Civil and Environmental Engineering, Virginia Tech , Blacksburg, Virginia United States.
Virginia Tech Global Change Center and Virginia Tech Institute of Critical Technology and Applied Science, Virginia Tech , Blacksburg, Virginia United States.
Environ Sci Technol. 2017 Nov 21;51(22):13061-13069. doi: 10.1021/acs.est.7b03623. Epub 2017 Oct 30.
Antibiotic resistance is a pervasive global health threat. To combat the spread of resistance, it is necessary to consider all possible sources and understand the pathways and mechanisms by which resistance disseminates. Best management practices are urgently needed to provide barriers to the spread of resistance and maximize the lifespan of antibiotics as a precious resource. Herein we advise upon the need for coordinated national and international strategies, highlighting three essential components: (1) Monitoring, (2) Risk Assessment, and (3) Mitigation of antibiotic resistance. Central to all three components is What exactly to monitor, assess, and mitigate? We address this question within an environmental framework, drawing from fundamental microbial ecological processes driving the spread of resistance.
抗生素耐药性是一个普遍存在的全球健康威胁。为了对抗耐药性的传播，有必要考虑所有可能的来源，并了解耐药性传播的途径和机制。迫切需要最佳管理实践，为耐药性的传播设置障碍，并最大限度地延长抗生素这一宝贵资源的使用寿命。在此，我们建议需要协调国家和国际战略，重点强调三个基本组成部分：（1）监测，（2）风险评估，以及（3）抗生素耐药性的缓解。所有三个组成部分的核心都是需要监测、评估和缓解什么？我们在环境框架内解决了这个问题，借鉴了推动耐药性传播的基本微生物生态过程。
