Faculty of Medicine, Landspitali University Hospital, University of Iceland, Reykjavik, Iceland.
Section of Cardiac Surgery, Yale University School of Medicine, New Haven, CT, USA.
Eur J Cardiothorac Surg. 2018 Jan 1;53(1):276-281. doi: 10.1093/ejcts/ezx231.
Acute Type A aortic dissection remains a life-threatening disease, but there are indications that its surgical mortality is decreasing. The aim of this report was to study how surgical mortality has changed and what influences those changes.
Nordic Consortium for Acute Type A Aortic Dissection is a retrospective database comprising 1159 patients (mean age 61.6 ± 12.2 years, 68% male) treated for acute Type A aortic dissection at 8 centres in Denmark, Finland, Iceland and Sweden from 2005 to 2014. Data gathered included demographics, symptoms, type of procedure, complications and 30-day mortality.
The annual number of operations increased significantly from 85 in 2005 to 150 in 2014 (P < 0.001). Chest pain was present in 85% of patients, 24% were hypotensive on presentation and 28% had malperfusion syndrome. Open distal anastomosis technique under hypothermic circulatory arrest was used in 85% of cases and its use increased significantly throughout the study. The 30-day mortality decreased from 24% in 2005 to 13% in 2014 (P = 0.003). Independent predictors for 30-day mortality were preoperative cardiac arrest, malperfusion syndrome, Penn Class C, Penn Class B and C and cardiopulmonary bypass time, whereas later calendar year and higher hospital operative volumes predicted improved survival.
Surgical mortality for acute Type A aortic dissection remains high but has decreased significantly over the last decade. This correlated with later year of operation and increased the number of operations performed per year, indicating that cumulative surgical experience contributes significantly to improved surgical outcomes.
急性 A 型主动脉夹层仍然是一种危及生命的疾病,但有迹象表明其手术死亡率正在下降。本报告的目的是研究手术死亡率是如何变化的,以及是什么影响了这些变化。
北欧急性 A 型主动脉夹层联合会是一个回顾性数据库,包含 2005 年至 2014 年在丹麦、芬兰、冰岛和瑞典的 8 个中心治疗的 1159 名急性 A 型主动脉夹层患者(平均年龄 61.6±12.2 岁,68%为男性)。收集的数据包括人口统计学、症状、手术类型、并发症和 30 天死亡率。
手术数量逐年显著增加,从 2005 年的 85 例增加到 2014 年的 150 例(P<0.001)。85%的患者存在胸痛,24%的患者就诊时低血压,28%的患者存在灌注不良综合征。85%的病例采用低温体外循环下的开放远端吻合技术,该技术的使用在整个研究过程中显著增加。30 天死亡率从 2005 年的 24%降至 2014 年的 13%(P=0.003)。30 天死亡率的独立预测因素包括术前心脏骤停、灌注不良综合征、Penn 分类 C、Penn 分类 B 和 C 以及体外循环时间,而较晚的年份和较高的医院手术量预示着生存率的提高。
急性 A 型主动脉夹层的手术死亡率仍然很高,但在过去十年中显著下降。这与手术年份的推移以及每年手术量的增加有关,表明累积的手术经验对手术结果的改善有重要贡献。