一种用于测定市售药品和废水样品中阿莫西林含量的分析方法的开发，以及评估其在模拟胃消化中的稳定性。
Development of an Analytical Method for the Determination of Amoxicillin in Commercial Drugs and Wastewater Samples, and Assessing its Stability in Simulated Gastric Digestion.
作者信息
Unutkan Tugçe, Bakirdere Sezgin, Keyf Seyfullah
机构信息
Chemical Engineering Department, Chemical and Metallurgical Engineering Faculty, Yildiz Technical University, 34210 Istanbul, Turkey.
Chemistry Department, Faculty of Art and Science, Yildiz Technical University, 34210 Istanbul, Turkey.
出版信息
J Chromatogr Sci. 2018 Jan 1;56(1):36-40. doi: 10.1093/chromsci/bmx078.
A highly sensitive analytical HPLC-UV method was developed for the determination of amoxicillin in drugs and wastewater samples at a single wavelength (230 nm). In order to substantially predict the in vivo behavior of amoxicillin, drug samples were subjected to simulated gastric conditions. The calibration plot of the method was linear from 0.050 to 500 mg L-1 with a correlation coefficient of 0.9999. The limit of detection and limit of quantitation were found to be 16 and 54 μg L-1, respectively. The percentage recovery of amoxicillin in wastewater was found to be 97.0 ± 1.6%. The method was successfully applied for the qualitative and quantitative determination of amoxicillin in drug samples including tablets and suspensions.
开发了一种高灵敏度的分析型高效液相色谱 - 紫外（HPLC - UV）方法，用于在单一波长（230 nm）下测定药物和废水样品中的阿莫西林。为了充分预测阿莫西林的体内行为，对药物样品进行了模拟胃部条件处理。该方法的校准曲线在0.050至500 mg L-1范围内呈线性，相关系数为0.9999。检测限和定量限分别为16和54 μg L-1。废水中阿莫西林的回收率为97.0 ± 1.6%。该方法成功应用于片剂和混悬液等药物样品中阿莫西林的定性和定量测定。
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