The Hydro-Chemistry Laboratory, Department of Geography and Environmental Studies, Tel Aviv University, Tel Aviv, Israel.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2009 Dec;44(14):1512-7. doi: 10.1080/10934520903263306.
The short half-life of aminopenicillin antibiotics in the aquatic environment put to the challenge the detection of their degradation products among environmental hydro-chemists. In a quest to study the occurrence of a new emerging micro-pollutant in the aquatic environment we attempted this by analyzing samples from a wastewater treatment plant for a major degradation product of amoxicillin (i.e., amoxicillin-diketopiperazine-2', 5') using a high-performance liquid chromatography technique coupled with tandem mass spectrometry method. ADP was repeatedly detected in all wastewater and effluent samples (18) from which it was extracted. To the best of our knowledge, this is the first study that evidently proves the occurrence of the chemically stable form of AMX, its Diketopiperazine-2', 5', in wastewater and effluent samples. Furthermore, penicillins are known to cause most allergic drug reactions. There is a risk that residues of hypersensitivity-inducing drugs, such as penicillins and their degradation products, may elicit allergic reactions in human consumers of water and food of animal origin.
在水环境中，氨基青霉素类抗生素的半衰期较短，这给环境水化学工作者检测其降解产物带来了挑战。为了研究新出现的微污染物在水环境中的发生情况，我们尝试通过分析来自一家污水处理厂的样品，使用高效液相色谱技术与串联质谱法，来检测阿莫西林的主要降解产物（即阿莫西林-二酮哌嗪-2'，5'）。在所有提取的废水和出水样本（18 个）中都反复检测到了 ADP。据我们所知，这是首次明确证明 AMX 的化学稳定形式及其二酮哌嗪-2'，5'在废水和出水样本中存在的研究。此外，青霉素已知会引起大多数过敏药物反应。具有致敏性的药物（如青霉素及其降解产物）的残留，可能会在人类饮用水和动物源性食品消费者中引发过敏反应。
