Gergely L, Czeglédy J, Váczi L
Institute of Microbiology, Medical University of Debrecen, Hungary.
Acta Virol. 1988 Jan;32(1):1-5.
Human antibody responses to human cytomegalovirus (HCMV) specific DNA-binding proteins were studied in serum samples by the Western blot technique. The molecular weights of six DNA-binding proteins found in HCMV-infected cells, ranged from 52kD to 18kD. The sera obtained from patients with acute HCMV infections reacted well with the six HCMV specific DNA-binding proteins. The strongest reactivity was observed with the 52kD and 35kD proteins. The sera from healthy HCMV seropositive donors reacted only with the 52kD DNA-binding protein as visualized in Western blots, but 2 out of 8 sera failed to react with any HCMV specific DNA-binding proteins.
采用蛋白质印迹技术，对血清样本中人类针对人巨细胞病毒（HCMV）特异性DNA结合蛋白的抗体反应进行了研究。在HCMV感染细胞中发现的六种DNA结合蛋白的分子量范围为52kD至18kD。急性HCMV感染患者的血清与这六种HCMV特异性DNA结合蛋白反应良好。观察到与52kD和35kD蛋白的反应最强。健康的HCMV血清阳性供体的血清在蛋白质印迹中仅与52kD DNA结合蛋白反应，但8份血清中有2份未能与任何HCMV特异性DNA结合蛋白反应。
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