Yuan Daozhang, Zheng Shunsheng, Wang Liyan, Li Jing, Yang Jianan, Wang Bin, Chen Xiong, Zhang Xiaobo
Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People's Republic of China.
Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Oncotarget. 2017 Jun 28;8(40):67663-67669. doi: 10.18632/oncotarget.18801. eCollection 2017 Sep 15.
Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c directly targets LDHA in bladder cancer cells. Ectopic expression of miR-200c inhibited LDHA-induced glycolysis, cell proliferation, and invasion. Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer.
乳酸脱氢酶A（LDHA）在多种癌症中过表达。我们研究了LDHA在膀胱癌中的表达及功能。我们证明，LDHA在膀胱癌细胞中上调，并促进细胞增殖、侵袭和糖酵解。此外，我们发现微小RNA（miR）-200c在膀胱癌细胞中直接靶向LDHA。miR-200c的异位表达抑制了LDHA诱导的糖酵解、细胞增殖和侵袭。因此，通过miR-200c靶向LDHA是膀胱癌的一种潜在治疗策略。
