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下丘脑神经内分泌基因表达：原位杂交组织化学研究

Neuroendocrine gene expression in the hypothalamus: in situ hybridization histochemical studies.

作者信息

Young W S, Zoeller R T

机构信息

Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892.

出版信息

Cell Mol Neurobiol. 1987 Dec;7(4):353-66. doi: 10.1007/BF00733788.

DOI:10.1007/BF00733788
PMID:2897879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11567446/
Abstract
  1. We have reviewed recent studies in which in situ hybridization histochemistry (ISHH) was used to investigate the regulation of expression of neurohypophysial peptides and hypothalamic releasing hormones. 2. ISHH is a technique in which the presence and quantity of a specific mRNA can be determined in tissue sections with a high degree of resolution and sensitivity. 3. ISHH has been used to measure changes in cellular levels of mRNAs encoding vasopressin, oxytocin, corticotropin-releasing factor, gonadotropin-releasing hormone, thyrotropin-releasing hormone and somatostatin in response to various physiological challenges. 4. A theme emerging from these studies is that changes in levels of mRNA encoding neuroendocrine peptides reflect changes in biosynthesis and secretion.
摘要
  1. 我们回顾了最近的一些研究，这些研究运用原位杂交组织化学（ISHH）来研究神经垂体肽和下丘脑释放激素表达的调控。2. ISHH是一种能够在组织切片中以高分辨率和高灵敏度测定特定mRNA的存在及数量的技术。3. ISHH已被用于测量编码抗利尿激素、催产素、促肾上腺皮质激素释放因子、促性腺激素释放激素、促甲状腺激素释放激素和生长抑素的mRNA细胞水平在各种生理刺激下的变化。4. 这些研究中出现的一个共同主题是，编码神经内分泌肽的mRNA水平的变化反映了生物合成和分泌的变化。

相似文献

1
Neuroendocrine gene expression in the hypothalamus: in situ hybridization histochemical studies.下丘脑神经内分泌基因表达：原位杂交组织化学研究
Cell Mol Neurobiol. 1987 Dec;7(4):353-66. doi: 10.1007/BF00733788.
2
The biological role of hypothalamic hypophysiotropic neuropeptides.下丘脑促垂体神经肽的生物学作用。
Adv Tech Stand Neurosurg. 1986;14:71-134. doi: 10.1007/978-3-7091-6995-7_3.
3
[Hypothalamic releasing hormones. I. Structure, sources of formation, physiologic effects].[下丘脑释放激素。I. 结构、生成来源、生理效应]
Usp Sovrem Biol. 1980 Jan-Feb;89(1):141-58.
4
Hypothalamic regulatory hormones.下丘脑调节激素。
Annu Rev Biochem. 1978;47:89-128. doi: 10.1146/annurev.bi.47.070178.000513.
5
The development of the releasing factor concept.释放因子概念的发展。
Clin Endocrinol (Oxf). 1976;5 Suppl:245S-260S. doi: 10.1111/j.1365-2265.1976.tb03833.x.
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[Hypophysiotropic factors, hypothalamus "hormone"].[促垂体激素因子，下丘脑“激素”]
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7
Twenty-four hour rhythms of hypothalamic corticotropin-releasing hormone, thyrotropin-releasing hormone, growth hormone-releasing hormone and somatostatin in rats injected with Freund's adjuvant.注射弗氏佐剂的大鼠下丘脑促肾上腺皮质激素释放激素、促甲状腺激素释放激素、生长激素释放激素和生长抑素的24小时节律
Biol Signals Recept. 1999 May-Jun;8(3):178-90. doi: 10.1159/000014588.
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[Molecular aspects of the hypothalamic hormones--brief review on the regulation and the function of CRH, TRH, GH-RH and LH-RH].
Nihon Rinsho. 1990 May;48(5):1053-60.
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Recently discovered hypothalamic-pituitary hormones.最近发现的下丘脑 - 垂体激素。
Clin Chem. 1976 Jan;22(1):5-15.
10
[Hypothalamic releasing and inhibiting hormones].[下丘脑释放激素和抑制激素]
Duodecim. 1973 Oct;20(1):1282-98.

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Endocrine. 1995 Jan;3(1):39-47. doi: 10.1007/BF02917447.
2
Luteinizing hormone-releasing hormone (LHRH) neurons maintained in hypothalamic slice explant cultures exhibit a rapid LHRH mRNA turnover rate.在下丘脑切片外植体培养物中维持的促黄体生成激素释放激素（LHRH）神经元表现出快速的LHRH mRNA周转速度。
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Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors.促性腺激素释放激素（GnRH）基因表达及相关生殖行为的激素与神经递质调节
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Neuron-specific expression and physiological regulation of bovine vasopressin transgenes in mice.牛加压素转基因在小鼠中的神经元特异性表达及生理调节
EMBO J. 1993 Jun;12(6):2397-409. doi: 10.1002/j.1460-2075.1993.tb05894.x.
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Radioimmunochemical methods for the quantitative autoradiographic determination of antigens in brain and other tissues.用于脑及其他组织中抗原定量放射自显影测定的放射免疫化学方法。
Cell Mol Neurobiol. 1988 Mar;8(1):57-70. doi: 10.1007/BF00712912.
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Galanin mRNA in the nucleus basalis of Meynert complex of baboons and humans.狒狒和人类迈内特复合体基底核中的甘丙肽信使核糖核酸
J Comp Neurol. 1991 Jan 1;303(1):113-20. doi: 10.1002/cne.903030110.
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Amplification of the in situ hybridization signal by silver postintensification: the biotin-dUTP-streptavidin-peroxidase diaminobenzidine-silver-gold detection system.银后增强原位杂交信号：生物素-dUTP-链霉亲和素-过氧化物酶-二氨基联苯胺-银-金检测系统
Histochemistry. 1991;96(4):339-42. doi: 10.1007/BF00271355.

本文引用的文献

1
[35S]cysteine labeled peptides transported to the neurohypophyses of adrenalectomized, lactating, and Brattleboro rats.[35S]半胱氨酸标记的肽被转运至肾上腺切除的、哺乳期的以及布拉特洛维大鼠的神经垂体。
Brain Res. 1980 Nov 10;201(1):227-34. doi: 10.1016/0006-8993(80)90791-x.
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Gonadotropin-releasing hormone (GnRH) in pituitary stalk blood from proestrous rats: effects of anesthetics and relationship between stored and released GnRH and luteinizing hormone.动情前期大鼠垂体柄血液中的促性腺激素释放激素（GnRH）：麻醉剂的影响以及储存与释放的GnRH和促黄体生成素之间的关系
Endocrinology. 1980 Nov;107(5):1410-7. doi: 10.1210/endo-107-5-1410.
3
Delineation of the hypothalamic area controlling thyrotropin secretion in the rat.大鼠中控制促甲状腺激素分泌的下丘脑区域的描绘。
Endocrinology. 1981 Nov;109(5):1731-8. doi: 10.1210/endo-109-5-1731.
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Effects of estradiol and progesterone on catecholamine turnover rates in discrete hypothalamic regions in ovariectomized rats.
Endocrinology. 1981 Jun;108(6):2186-93. doi: 10.1210/endo-108-6-2186.
5
Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.抗利尿激素基因中的单碱基缺失是布拉德福德大鼠尿崩症的病因。
Nature. 1984;308(5961):705-9. doi: 10.1038/308705a0.
6
Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides.用合成寡核苷酸杂交法评估大鼠中血管加压素和催产素mRNA的调控
J Biol Chem. 1983 Dec 10;258(23):14061-4.
7
Corticotropin-releasing factor: co-expression within distinct subsets of oxytocin-, vasopressin-, and neurotensin-immunoreactive neurons in the hypothalamus of the male rat.促肾上腺皮质激素释放因子：在雄性大鼠下丘脑催产素、加压素和神经降压素免疫反应性神经元的不同亚群内共表达。
J Neurosci. 1984 Apr;4(4):1118-29. doi: 10.1523/JNEUROSCI.04-04-01118.1984.
8
Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy.肾上腺切除术后，室旁核中促肾上腺皮质激素释放因子免疫反应性神经元变为加压素阳性。
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1854-8. doi: 10.1073/pnas.81.6.1854.
9
Ability of the CRF immunoreactive neurons of the paraventricular nucleus to produce a vasopressin-like material. Immunohistochemical demonstration in adrenalectomized guinea pigs and rats.室旁核促肾上腺皮质激素释放因子免疫反应性神经元产生血管加压素样物质的能力。在肾上腺切除的豚鼠和大鼠中的免疫组织化学证明
Neuroendocrinology. 1983 Dec;37(6):467-9. doi: 10.1159/000123595.
10
Comparative immunocytochemical localization of corticotropin releasing factor (CRF-41) and neurohypophysial peptides in the brain of Brattleboro and Long-Evans rats.布拉特洛维大鼠和长-伊文斯大鼠大脑中促肾上腺皮质激素释放因子（CRF-41）与神经垂体肽的免疫细胞化学定位比较
Neuroendocrinology. 1983 Jul;37(1):64-72. doi: 10.1159/000123517.