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自闭症儿童甲状腺功能、血清25-羟基维生素D及分化簇5表达水平的生化评估。

Biochemical assessments of thyroid profile, serum 25-hydroxycholecalciferol and cluster of differentiation 5 expression levels among children with autism.

作者信息

Desoky Tarek, Hassan Mohammed H, Fayed Hanan M, Sakhr Hala M

机构信息

Department of Neuropsychiatry.

Department of Medical Biochemistry and Molecular Biology.

出版信息

Neuropsychiatr Dis Treat. 2017 Sep 14;13:2397-2403. doi: 10.2147/NDT.S146152. eCollection 2017.

Abstract

BACKGROUND

The exact pathogenesis of autism is still unknown. Both thyroid hormones and 25(OH)D are important for brain development, in addition to CD5; all have immunomodulatory actions by which their dysregulation may have a potential role in autism pathogenesis.

OBJECTIVES

The objectives of this study were to assess the thyroid profile, serum 25(OH)D levels and CD5 expression levels among autistic patients and to find out the correlations between the measured biomarkers with each other on one side and with the disease severity on the other side.

PATIENTS AND METHODS

This cross-sectional case-control study has been conducted on 60 children with autism and 40 controls, recruited from Qena Governorate, Upper Egypt. Childhood Autism Rating Scale (CARS) score was used to assess the included patients. Biochemical assays of thyroid function in the form of free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroid-stimulating hormone (TSH) and 25(OH)D were done using commercially available enzyme-linked immunosorbent assay (ELISA) kits, while CD5 expression levels were measured using flow cytometry (FCM) analysis for all the included patients and controls.

RESULTS

The overall measurement results show significant higher mean serum TSH levels, mean CD5 expression levels with significant lower mean serum 25(OH)D levels among autistic children when compared with the control group (<0.05 for all). Significant negative correlations between CD5 with FT3, FT4 and 25(OH)D were observed. CARS score showed significant negative correlations with both FT3 and 25(OH)D, while it was positively correlated with CD5 in a significant manner (<0.05 for all).

CONCLUSION

Elevated CD5 expression and decreased 25(OH)D stores could play a potential role in the pathogenesis of autism via their immune-modulator actions. High TSH serum levels among autistic children, although within the physiological range, reflect the presence of thyroid dysfunction among such children, which needs further assessment.

摘要

背景

自闭症的确切发病机制仍不清楚。甲状腺激素和25(OH)D对大脑发育都很重要,此外还有CD5;它们都具有免疫调节作用,其失调可能在自闭症发病机制中发挥潜在作用。

目的

本研究的目的是评估自闭症患者的甲状腺功能指标、血清25(OH)D水平和CD5表达水平,并找出所测生物标志物之间以及它们与疾病严重程度之间的相关性。

患者与方法

本横断面病例对照研究对从埃及上埃及基纳省招募的60名自闭症儿童和40名对照进行。使用儿童自闭症评定量表(CARS)评分对纳入的患者进行评估。采用市售酶联免疫吸附测定(ELISA)试剂盒对游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)和25(OH)D形式的甲状腺功能进行生化检测,同时对所有纳入的患者和对照使用流式细胞术(FCM)分析测量CD5表达水平。

结果

总体测量结果显示,与对照组相比,自闭症儿童的血清TSH平均水平显著升高,CD5平均表达水平显著升高,而血清25(OH)D平均水平显著降低(所有P<0.05)。观察到CD5与FT3、FT4和25(OH)D之间存在显著负相关。CARS评分与FT3和25(OH)D均呈显著负相关,而与CD5呈显著正相关(所有P<0.05)。

结论

CD5表达升高和25(OH)D储备减少可能通过其免疫调节作用在自闭症发病机制中发挥潜在作用。自闭症儿童血清TSH水平升高,尽管在生理范围内,但反映了此类儿童存在甲状腺功能障碍,需要进一步评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae1/5608227/6c31bb888280/ndt-13-2397Fig1.jpg

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