Robertson Alexander R, Kennedy Nicholas A, Robertson James A, Church Nicholas I, Noble Colin L
Department of Gastroenterology, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.
Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.
World J Gastrointest Endosc. 2017 Sep 16;9(9):471-479. doi: 10.4253/wjge.v9.i9.471.
To compare colonoscopy quality with nitrous oxide gas (Entonox) against intravenous conscious sedation using midazolam plus opioid.
A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in Lothian health board hospitals between July 2013 and January 2016. The quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation (abbreviated in this article as IVM). Furthermore, the quality of colonoscopies performed with an unmedicated group was compared to IVM. The study used the following key markers of colonoscopy quality: (1) patient comfort scores; (2) caecal intubation rates (CIRs); and (3) polyp detection rates (PDRs). We used binary logistic regression to model the data.
There was no difference in the rate of moderate-to-extreme discomfort between the Entonox and IVM groups (17.9% 18.8%; OR = 1.06, 95%CI: 0.95-1.18, = 0.27). Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group (11.4% 18.8%; OR = 0.71, 95%CI: 0.60-0.83, < 0.001). There was no difference in caecal intubation between the Entonox and IVM groups (94.4% 93.7%; OR = 1.08, 95%CI: 0.92-1.28, = 0.34). There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% 93.7%; OR = 0.98, 95%CI: 0.79-1.22, = 0.87). Polyp detection in the Entonox group was not different from IVM group (35.0% 33.1%; OR = 1.01, 95%CI: 0.93-1.10, = 0.79). Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% 33.1%; OR = 0.97, 95%CI: 0.87-1.08, = 0.60).
The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid.
比较使用氧化亚氮气体（安桃乐）与使用咪达唑仑加阿片类药物进行静脉清醒镇静时的结肠镜检查质量。
对2013年7月至2016年1月在洛锡安卫生委员会医院进行的18608例结肠镜检查的前瞻性数据库进行回顾性分析。将使用安桃乐进行的结肠镜检查质量与静脉清醒镇静（本文简称为IVM）进行比较。此外，将未用药组进行的结肠镜检查质量与IVM进行比较。该研究使用了以下结肠镜检查质量的关键指标：（1）患者舒适度评分；（2）盲肠插管率（CIRs）；（3）息肉检出率（PDRs）。我们使用二元逻辑回归对数据进行建模。
安桃乐组与IVM组之间中度至极度不适的发生率无差异（17.9%对18.8%；OR = 1.06，95%CI：0.95 - 1.18，P = 0.27）。未用药组患者比IVM组患者经历中度至极度不适的可能性更小（11.4%对18.8%；OR = 0.71，95%CI：0.60 - 0.83，P < 0.001）。安桃乐组与IVM组之间的盲肠插管情况无差异（94.4%对93.7%；OR = 1.08，95%CI：0.92 - 1.28，P = 0.34）。未用药组与IVM组之间的盲肠插管情况无差异（94.2%对93.7%；OR = 0.98，95%CI：0.79 - 1.22，P = 0.87）。安桃乐组的息肉检出情况与IVM组无差异（35.0%对33.1%；OR = 1.01，95%CI：0.93 - 1.10，P = 0.79）。未用药组的息肉检出情况与IVM组无显著差异（37.4%对33.1%；OR = 0.97，95%CI：0.87 - 1.
