Xu Bin, Aryeequaye Ruth, Wang Lu, Katabi Nora
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Head Neck Pathol. 2018 Jun;12(2):274-278. doi: 10.1007/s12105-017-0855-5. Epub 2017 Oct 4.
Secretory carcinoma (SC) is a recently described salivary gland carcinoma with characteristic ETV6-NTRK3 fusion. In this case report, we described a SC of the maxillary sinus that underwent high grade transformation in a 61-year-old patient. The diagnosis was confirmed by the presence of ETV6 translocation. Within the sinonasal tract, SC is an important differential diagnosis especially of sinonasal adenocarcinoma, non-intestinal type (non-ITAC), as these two entities bears histologic and immunophenotypic similarity. Distinction between these two tumors can be challenging based on the morphology alone and may require additional immunohistochemical and molecular studies. It is important to recognize that SC can occur in the sinonasal tract as correctly diagnosing SC may be prognostic relevant and may provide new targeted therapeutic avenues for these patients.
分泌性癌（SC）是一种最近才被描述的涎腺癌，具有特征性的ETV6-NTRK3融合基因。在本病例报告中，我们描述了一名61岁患者上颌窦的分泌性癌发生了高级别转化。通过检测到ETV6易位确诊。在鼻窦道内，分泌性癌是一个重要的鉴别诊断对象，尤其是与鼻窦腺癌、非肠型（非ITAC）的鉴别，因为这两种实体在组织学和免疫表型上具有相似性。仅根据形态学区分这两种肿瘤可能具有挑战性，可能需要额外的免疫组化和分子研究。认识到分泌性癌可发生于鼻窦道很重要，因为正确诊断分泌性癌可能与预后相关，并可能为这些患者提供新的靶向治疗途径。
