Department of Obstetrics and Gynecology, Christian Medical College, Vellore, India.
Department of Clinical Microbiology, Christian Medical College, Vellore, India.
Int J Gynaecol Obstet. 2018 Jan;140(1):42-46. doi: 10.1002/ijgo.12336. Epub 2017 Oct 27.
To determine the prevalence of syphilis in pregnancy and to assess the effect of syphilis on maternal and perinatal outcomes.
In a retrospective study, data were reviewed for pregnant women who tested positive for syphilis during routine prenatal screening at a center in India between January 2011 and December 2015. Women with both a positive venereal disease research laboratory (VDRL) test and a positive Treponema pallidum hemagglutination assay (TPHA) were considered to have syphilis, and their maternal and fetal outcomes were assessed.
Among 51 164 pregnant women who underwent VDRL testing during the study period, 343 women were VDRL-positive (seropositivity rate 0.7%) and 18 were both VDRL- and TPHA-positive and were considered to have syphilis (seropositivity rate <0.1%). Among these 18 women, there were two stillbirths, four preterm births, and five small-for-gestational-age neonates.
Although the prevalence of syphilis was low in the study population, women who were affected had adverse perinatal outcomes. Routine screening of all pregnant women for syphilis as early as possible in pregnancy, with appropriate treatment and follow-up of affected women and newborns, should be done to reduce adverse pregnancy outcomes.
确定妊娠梅毒的流行率，并评估梅毒对母婴围生结局的影响。
在一项回顾性研究中，分析了 2011 年 1 月至 2015 年 12 月期间在印度某中心进行常规产前筛查时梅毒血清学阳性的孕妇数据。对同时进行 VDRL 检测和梅毒螺旋体血凝试验（TPHA）检测均为阳性的孕妇进行梅毒诊断，并评估其母婴结局。
在研究期间接受 VDRL 检测的 51164 例孕妇中，343 例 VDRL 阳性（血清阳性率 0.7%），18 例 VDRL 和 TPHA 均阳性，被诊断为梅毒（血清阳性率<0.1%）。这 18 例孕妇中，有 2 例死胎，4 例早产，5 例小于胎龄儿。
尽管研究人群中梅毒的流行率较低，但受感染的孕妇围生结局较差。应尽早对所有孕妇进行梅毒常规筛查，对受感染的孕妇及其新生儿进行适当的治疗和随访，以降低不良妊娠结局的发生。
