Zheng Xiaofan, Ding Wei, Ling Xia, Shi Jie, Dong Jie, Yu Guangshu, Chen Yan, Li Rui, Xu Lihong, Li Xiaotao, Zhu Hong, Zhu Faming, Hu Wei
Blood Center of Zhejiang Province, Hangzhou, Zhejiang 310052, China.
Key Laboratory of Blood Safety Research of Zhejiang Province, Hangzhou, Zhejiang 310052, China.
Can J Infect Dis Med Microbiol. 2022 Aug 8;2022:1668703. doi: 10.1155/2022/1668703. eCollection 2022.
Infection with syphilis is still a major public health problem. The precise data for syphilis seroprevalence in the populations will help to develop a strategy for prevention and treatment of it. However, the data for syphilis prevalence in continuous years among volunteer blood donors in China is rare.
A retrospective study for (TP) antibody in blood donors was conducted from January 2010 to December 2019 at the Blood Center of Zhejiang Province, China. TP antibody was detected with two different reagents using enzyme-linked immunosorbent assay and the only sample which was reactive in the two reagents was defined as seropositive.
A total of 992,646 volunteer blood donors were analyzed and the positive rate of TP antibody in the blood donors was 0.43%. From 2010 to 2019, the positive rates of TP antibody were 0.53%, 0.51%, 0.51%, 0.43%, 0.36%, 0.18%, 0.11%, 0.12%, 0.11%, and 0.10%, respectively. The positive rates of TP antibody were significantly different among blood donor age group ( < 0.001), with the highest positive rate in 45-54-years-old group (0.93%). The positive rates of TP antibody in male and female blood donors were 0.44% and 0.41%, respectively. The positive rate was 0.57% among the first-time blood donors, which was significantly higher than that of the repeat blood donors (0.17%). The positive rate of TP antibody in blood donors decreased gradually with the increase of educational level.
The syphilis seroprevalence is low in the blood donors of the Hangzhou area, and the positive rate of blood donors is associated with age, educational level, and times of blood donation. Increasing the number of repeat blood donations is helpful to improve blood safety.
梅毒感染仍是一个主要的公共卫生问题。人群中梅毒血清流行率的确切数据将有助于制定梅毒的预防和治疗策略。然而，中国无偿献血者连续多年的梅毒流行率数据很少。
对2010年1月至2019年12月在中国浙江省血液中心的献血者进行梅毒螺旋体（TP）抗体的回顾性研究。采用酶联免疫吸附试验用两种不同试剂检测TP抗体，两种试剂均呈反应性的唯一样本定义为血清学阳性。
共分析了992646名无偿献血者，献血者中TP抗体阳性率为0.43%。2010年至2019年，TP抗体阳性率分别为0.53%、0.51%、0.51%、0.43%、0.36%、0.18%、0.11%、0.12%、0.11%和0.10%。献血者年龄组间TP抗体阳性率差异有统计学意义（P<0.001），45 - 54岁组阳性率最高（0.93%）。男性和女性献血者TP抗体阳性率分别为0.44%和0.41%。首次献血者阳性率为0.57%，显著高于多次献血者（0.17%）。献血者TP抗体阳性率随文化程度升高而逐渐降低。
杭州地区献血者梅毒血清流行率较低，献血者阳性率与年龄、文化程度和献血次数有关。增加多次献血人数有助于提高血液安全性。
