a Biological Systems and Engineering Division , Lawrence Berkeley National Laboratory , Department of Molecular and Cell Biology , University of California , Berkeley , CA , USA.
b Department of Pathology and Laboratory Medicine , Lineberger Comprehensive Cancer Center , University of North Carolina , Chapel Hill , NC , USA.
Cell Cycle. 2017;16(24):2323-2325. doi: 10.1080/15384101.2017.1387698. Epub 2017 Dec 6.
Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.
染色体不稳定性（CIN）促进了许多癌症的发展。在本文中，我们总结了最近的发现，即 FBW7 缺失通过细胞周期蛋白 E1/CDK2 促进着丝粒蛋白 A（CENP-A）丝氨酸 18 上的磷酸化，从而促进 CIN 和肿瘤发生的新途径。我们的发现表明 CENP-A 翻译后修饰在调节癌症中着丝粒和有丝分裂功能的重要性。
