a Department of Psychiatry , Arak University of Medical Sciences , Arak , Iran.
b Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics , School of Medicine, Arak University of Medical Sciences , Arak , Iran.
J Psychosom Obstet Gynaecol. 2018 Dec;39(4):307-314. doi: 10.1080/0167482X.2017.1383381. Epub 2017 Oct 5.
Data on comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with polycystic ovary syndrome (PCOS) are scarce. This purpose of this study was to compare of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with PCOS.
This randomized controlled trial was conducted among 60 subjects diagnosed with PCOS according to the Rotterdam criteria. Subjects were randomly assigned into two groups to intake either myo-inositol (n = 30) or metformin (n = 30) for 12 weeks. Parameters of mental health were recorded at baseline and after the 12-week intervention. Fasting blood samples were obtained at baseline and the end of the study to determine biomarkers of biomarkers of oxidative stress.
After the 12-week intervention, changes in beck depression inventory total score (-1.0 ± 1.7 vs. -0.3 ± 0.7, p = 0.03), general health questionnaire scores (-1.7 ± 2.9 vs. -0.5 ± 1.2, p = 0.02), depression anxiety and stress scale scores (-3.9 ± 6.4 vs. -0.9 ± 1.9, p = 0.01) and plasma total antioxidant capacity (TAC) concentrations (+106.1 ± 69.6 vs. +2.1 ± 132.4 mmol/L, p < 0.001) in the myo-inositol group were significantly different from the changes in these indicators in the metformin group. Myo-inositol supplementation for 12 weeks among patients with PCOS did not affect plasma glutathione and malondialdehyde levels.
Overall, our data supported that myo-inositol supplementation for 12 weeks among patients with PCOS had favorable effects on parameters of mental health and plasma TAC levels.
关于多囊卵巢综合征（PCOS）患者中肌醇和二甲双胍对心理健康参数和氧化应激生物标志物的比较的数据很少。本研究的目的是比较肌醇和二甲双胍对 PCOS 患者心理健康参数和氧化应激生物标志物的影响。
这项随机对照试验在根据 Rotterdam 标准诊断为 PCOS 的 60 名受试者中进行。受试者随机分为两组，分别服用肌醇（n=30）或二甲双胍（n=30），疗程为 12 周。在基线和 12 周干预后记录心理健康参数。在基线和研究结束时采集空腹血样，以确定氧化应激生物标志物。
干预 12 周后，贝克抑郁量表总分变化（-1.0±1.7 与-0.3±0.7，p=0.03）、一般健康问卷评分变化（-1.7±2.9 与-0.5±1.2，p=0.02）、抑郁焦虑和压力量表评分变化（-3.9±6.4 与-0.9±1.9，p=0.01）和血浆总抗氧化能力（TAC）浓度变化（+106.1±69.6 与+2.1±132.4mmol/L，p<0.001）在肌醇组与二甲双胍组的变化有显著差异。肌醇补充 12 周对 PCOS 患者的血浆谷胱甘肽和丙二醛水平没有影响。
总的来说，我们的数据支持 PCOS 患者补充肌醇 12 周对心理健康参数和血浆 TAC 水平有有益的影响。
