Rostami Somayeh, Arefhosseini Sara, Tutunchi Helda, Khoshbaten Manouchehr, Ebrahimi-Mameghani Mehrangiz
Student Research Committee, Faculty of Nutrition & Food Sciences Tabriz University of Medical Sciences Tabriz Iran.
Endocrine Research Center Tabriz University of Medical Sciences Tabriz Iran.
Food Sci Nutr. 2023 Dec 6;12(2):1279-1289. doi: 10.1002/fsn3.3842. eCollection 2024 Feb.
Myo-inositol (MI) is a carbocyclic sugar polyalcohol. MI has known to exert anti-inflammatory, anti-oxidant, and anti-diabetic activities. This study aimed to investigate the effects of MI supplementation on oxidative stress biomarkers in obese patients with non-alcoholic fatty liver disease (NAFLD). In this double-blinded placebo-controlled randomized clinical trial, 51 newly diagnosed obese patients with NAFLD were randomly assigned to receive either MI (4 g/day) or placebo supplements accompanied by dietary recommendations for 8 weeks. Oxidative stress biomarkers, nutritional status, as well as liver enzymes and obesity indices were assessed pre- and post-intervention. A total of 48 patients completed the trial. Although anthropometric measures and obesity indices decreased significantly in both groups, the between-group differences adjusted for confounders were non-significant for these parameters, except for weight ( = .049); greater decrease was observed in the MI group. Iron and zinc intakes decreased significantly in both groups; however, between-group differences were non-significant at the end of the study. No significant between-group differences were revealed for other antioxidant micronutrients at the study endpoint. Sense of hunger, feeling to eat, desire to eat sweet and fatty foods reduced significantly in both groups ( < .05), while the feeling of satiety increased significantly in the placebo group ( = .002). No significant between-group differences were observed for these parameters, except for desire to eat fatty foods; a greater decrease was observed in the MI group ( = .034). Serum levels of glutathione peroxidase (GPx) and superoxide dismutase (SOD) significantly increased in both study groups ( < .05); however, the between-group differences were non-significant at the end of the study. Furthermore, the between-group differences were non-significant for other oxidative stress biomarkers, except for serum nitric oxide (NO) level; a greater decrease was observed in the MI group. MI supplementation could significantly improve weight, desire to eat fatty foods, serum levels of NO, as well as the aspartate aminotransferase (AST)/ALT ratio.
肌醇（MI）是一种碳环糖醇。已知MI具有抗炎、抗氧化和抗糖尿病活性。本研究旨在探讨补充MI对非酒精性脂肪性肝病（NAFLD）肥胖患者氧化应激生物标志物的影响。在这项双盲安慰剂对照随机临床试验中，51名新诊断的NAFLD肥胖患者被随机分配接受MI（4克/天）或安慰剂补充剂，并伴有饮食建议，为期8周。在干预前后评估氧化应激生物标志物、营养状况以及肝酶和肥胖指数。共有48名患者完成了试验。尽管两组的人体测量指标和肥胖指数均显著下降，但在调整混杂因素后，除体重外（P = 0.049），这些参数的组间差异无统计学意义；MI组的下降幅度更大。两组的铁和锌摄入量均显著下降；然而，在研究结束时，组间差异无统计学意义。在研究终点，其他抗氧化微量营养素的组间差异无统计学意义。两组的饥饿感、进食欲望、想吃甜食和油腻食物的欲望均显著降低（P < 0.05），而安慰剂组的饱腹感显著增加（P = 0.002）。除了想吃油腻食物的欲望外，这些参数的组间差异无统计学意义；MI组的下降幅度更大（P = 0.034）。两个研究组的血清谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）水平均显著升高（P < 0.05）；然而，在研究结束时，组间差异无统计学意义。此外，除血清一氧化氮（NO）水平外，其他氧化应激生物标志物的组间差异无统计学意义；MI组的下降幅度更大。补充MI可显著改善体重、想吃油腻食物的欲望、血清NO水平以及天冬氨酸转氨酶（AST）/丙氨酸转氨酶（ALT）比值。
