Takagi Sahoko, Naito Mariko, Kawai Sayo, Okada Rieko, Nagata Chisato, Hosono Satoyo, Nishida Yuichiro, Takashima Naoyuki, Suzuki Sadao, Shimoshikiryo Ippei, Mikami Haruo, Uemura Hirokazu, Kuriyama Nagato, Ohnaka Keizo, Kubo Michiaki, Hamajima Nobuyuki, Tanaka Hideo, Wakai Kenji
1Department of Preventive Medicine,Nagoya University Graduate School of Medicine,65 Tsurumai-cho,Showa-ku,Nagoya 466-8550,Japan.
2Department of Epidemiology and Preventive Medicine,Gifu University Graduate School of Medicine,1-1 Yanagido,Gifu 501-1194,Japan.
Br J Nutr. 2017 Sep;118(6):463-472. doi: 10.1017/S0007114517002239.
Although higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47-69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study. We documented dietary intakes, measured serum concentrations of oestrone (E1) and oestradiol (E2) and genotyped polymorphisms in oestrogen-metabolising CYP19A1 (rs4441215 and rs936306) and HSD17B1 (rs605059) genes. Trends and interactions were examined using linear regression models. In addition, we calculated the ratios of the oestrogen concentrations of the second to the highest quartiles (Q2-Q4) of dietary intake to those of the lowest quartiles (Q1). After adjustment for potential confounders, E2 was significantly associated with intake of carbohydrate and noodles; ratios of Q4 v. Q1 were 1·15 (95 % CI 1·04, 1·28) and 1·15 (95 % CI 1·04, 1·26), respectively. In contrast, E2 levels were inversely associated with intake of total energy, SFA and n-3 highly unsaturated fatty acids (n-3 HUFA); ratios of Q4 v. Q1 were 0·90 (95 % CI 0·82, 0·99), 0·89 (95 % CI 0·81, 0·98) and 0·91 (95 % CI 0·83, 1·00), respectively. In stratified analysis by polymorphisms, the rs605059 genotype of HSD17B1 significantly modified associations of E2 with intake of n-3 HUFA and fish; the associations were limited to those with the CC genotype. Macronutrient intakes were associated with serum E2 level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal women.
尽管循环中较高水平的雌激素与绝经后乳腺癌风险相关，但关于饮食对内源性雌激素影响的信息有限。因此，我们在考虑雌激素代谢基因多态性的情况下，研究了常量营养素摄入量与血清雌激素之间的关联。在这项横断面研究中，从日本多机构合作队列研究的参与者中选取了784名年龄在47 - 69岁的自然绝经日本女性。我们记录了她们的饮食摄入量，测量了血清雌酮（E1）和雌二醇（E2）的浓度，并对雌激素代谢相关的CYP19A1（rs4441215和rs936306）和HSD17B1（rs605059）基因进行基因分型。使用线性回归模型研究趋势和相互作用。此外，我们计算了饮食摄入量第二至最高四分位数（Q2 - Q4）的雌激素浓度与最低四分位数（Q1）的雌激素浓度之比。在对潜在混杂因素进行调整后，E2与碳水化合物和面条的摄入量显著相关；Q4与Q1的比值分别为1.15（95%CI 1.04，1.28）和1.15（95%CI 1.04，1.26）。相比之下，E2水平与总能量、饱和脂肪酸（SFA）和n - 3高度不饱和脂肪酸（n - 3 HUFA）的摄入量呈负相关；Q4与Q1的比值分别为0.90（95%CI 0.82，0.99）、0.89（95%CI 0.81，0.98）和0.91（95%CI 0.83，1.00）。在按多态性进行的分层分析中，HSD17B1的rs605059基因型显著改变了E2与n - 3 HUFA和鱼类摄入量之间的关联；这些关联仅限于CC基因型的女性。常量营养素摄入量与血清E2水平相关，并且在绝经后女性中，这些关联可能会因HSD17B1多态性而改变。
