Shimizu H, Ross R K, Bernstein L, Pike M C, Henderson B E
Department of Public Health, Gifu University School of Medicine, Japan.
Br J Cancer. 1990 Sep;62(3):451-3. doi: 10.1038/bjc.1990.316.
Serum oestrone (E1), oestradiol (E2) and sex hormone binding globulin (SHBG) levels were studied in postmenopausal Japanese women in Japan (n = 91) and postmenopausal American white women (n = 38). The Japanese women were deliberately chosen to be from a rural agricultural area in order to get samples which represent as closely as possible the traditional Japanese 'lifestyle' that gave rise to the low rates of breast cancer in Japan. E1 levels were 47%, and E2 levels 36%, greater in the American women; these differences were only reduced to 43% and 27% after adjustment for the lower weight of the Japanese. These results were all statistically highly significant. There was little difference in SHBG levels between the Japanese and the American women. These results for E1 and E2 could be an important part of the explanation why Japanese and American breast cancer rates continue to diverge further after the menopause.
对日本绝经后日本女性（n = 91）和绝经后美国白人女性（n = 38）的血清雌酮（E1）、雌二醇（E2）和性激素结合球蛋白（SHBG）水平进行了研究。特意选择日本女性来自农村农业地区，以便获取尽可能能代表导致日本乳腺癌低发病率的传统日本“生活方式”的样本。美国女性的E1水平高47%，E2水平高36%；在对日本人体重较低进行校正后，这些差异仅降至43%和27%。这些结果在统计学上均具有高度显著性。日本女性和美国女性的SHBG水平几乎没有差异。E1和E2的这些结果可能是绝经后日本和美国乳腺癌发病率继续进一步分化的重要解释部分。
