Sawicka Karolina, Michalska-Jakubus Małgorzata, Kowal Małgorzata, Potembska Emilia, Krasowska Dorota
Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Poland.
Department of Psychiatric Nursing, Medical University of Lublin, Poland.
Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):144-150. Epub 2017 Sep 18.
Resistin has strong pro-inflammatory and profibrotic properties, which are key pathogenetic processes in systemic sclerosis. We hypothesised that resistin may be associated with organ involvement and inflammatory process in SSc patients. To address this hypothesis, the aim of this study was to define serum resistin levels in SSc patients and control group and determine the correlation between this adipokine and internal organ involvement in SSc patients.
The study enrolled 48 Caucasian female patients with SSc and 38 healthy subjects of control group. Serum concentrations of resistin were measured using commercially available ELISA Kits (Quantikine ELISA Kit R & D Systems, Minneapolis, MN, USA).
Patients with SSc had higher resistin levels [mean (SD): 10.2, (4.87)] than the control group [7.64, (4.43)] and the difference was statistically significant (p=0.017, p<0.05). We found statistically significant association between serum resistin and ILD, arthralgia and oesophageal involvement (r=0.31, p=0.042; r=0.48, p=0.001; r=0.32, p=0.034; respectively). Moreover, the assessment of the relation between plasma concentrations of resistin and inflammatory parameters in SSc patients indicated a positive correlation between resistin and C-reactive protein levels (r=0.37; p=0.011).
The results of our study indicate that resistin levels might correlate with organ involvement and inflammatory process in SSc patients.
抵抗素具有很强的促炎和促纤维化特性，而这是系统性硬化症的关键发病机制。我们推测抵抗素可能与系统性硬化症（SSc）患者的器官受累及炎症过程有关。为验证这一假设，本研究旨在测定SSc患者和对照组的血清抵抗素水平，并确定这种脂肪因子与SSc患者内脏器官受累之间的相关性。
本研究纳入了48例患有SSc的白人女性患者和38例对照组健康受试者。使用市售酶联免疫吸附测定试剂盒（Quantikine ELISA试剂盒，R&D Systems，明尼阿波利斯，美国明尼苏达州）测量血清抵抗素浓度。
SSc患者的抵抗素水平[均值（标准差）：10.2，（4.87）]高于对照组[7.64，（4.43）]，差异具有统计学意义（p = 0.017，p < 0.05）。我们发现血清抵抗素与间质性肺病、关节痛和食管受累之间存在统计学意义的关联（分别为r = 0.31，p = 0.042；r = 0.48，p = 0.001；r = 0.32，p = 0.034）。此外，对SSc患者抵抗素血浆浓度与炎症参数之间关系的评估表明，抵抗素与C反应蛋白水平呈正相关（r = 0.37；p = 0.011）。
我们的研究结果表明，抵抗素水平可能与SSc患者的器官受累及炎症过程相关。
