Department of Translational and Precision Medicine, Lazio, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
Unit of Allergology, Clinical Immunology and Rheumatology, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
Clin Exp Med. 2022 Aug;22(3):421-426. doi: 10.1007/s10238-021-00756-2. Epub 2021 Aug 30.
Systemic sclerosis (SSc) is autoimmune disease characterized by endothelial dysfunction and microvascular damage. Resistin has been implied in microvascular dysfunction. Objective of this study is to evaluate the association between baseline resistin and development of new digital ulcers (DUs) in SSc patients. At baseline, serum resistin has been assessed in 70 female SSc patients and 26 healthy controls (HC). In SSc patients, clinical assessment was performed at baseline and after a 52-weeks follow-up. Serum resistin level was increased in SSc patients compared to HC [5.89 ng/ml (2.5 ng/ml-8.1 ng/ml) vs 2.3 ng/ml (0.4 ng/ml-2.4 ng/ml), p = 0.0004)]. Resistin was lower (p = 0.005) in SSc patients with early capillaroscopic pattern than patients with active or late capillaroscopic pattern [2.49 ng/ml (0.89 ng/ml-5.81 ng/ml) vs 7.11 ng/ml (3.48 ng/ml-11.35 ng/ml) and 6.49 ng/ml (3.35 ng/ml-8.87 ng/ml), respectively]. After a 52-weeks follow-up, 34 (48.6%) patients developed new DUs. Median serum resistin was significantly higher in patients with new DUs than in patients without new DUs [6.54 ng/ml (3.35 ng/ml-11.02 ng/ml) vs 4.78 ng/ml (1.06 ng/ml-7.6 ng/ml), p = 0.019]. Kaplan-Meier curves show a significantly reduced free survival from DUs in patients with increased resistin (p = 0.002). In multivariate analysis, resistin is associated with the development of new DUs. Increased serum resistin level is a predictive marker of new DUs in SSc.
系统性硬化症（SSc）是一种自身免疫性疾病，其特征为内皮功能障碍和微血管损伤。抵抗素与微血管功能障碍有关。本研究旨在评估基线抵抗素与 SSc 患者新发手指溃疡（DU）之间的相关性。在基线时，评估了 70 名女性 SSc 患者和 26 名健康对照者（HC）的血清抵抗素水平。在 SSc 患者中，在基线时和 52 周随访时进行了临床评估。与 HC 相比，SSc 患者的血清抵抗素水平升高[5.89ng/ml（2.5ng/ml-8.1ng/ml）比 2.3ng/ml（0.4ng/ml-2.4ng/ml），p=0.0004]。与活动期或晚期毛细血管模式的患者相比，具有早期毛细血管模式的 SSc 患者的抵抗素水平更低（p=0.005）[2.49ng/ml（0.89ng/ml-5.81ng/ml）比 7.11ng/ml（3.48ng/ml-11.35ng/ml）和 6.49ng/ml（3.35ng/ml-8.87ng/ml）]。经过 52 周的随访，34 名（48.6%）患者出现新的 DU。新发 DU 患者的中位血清抵抗素水平明显高于无新发 DU 患者[6.54ng/ml（3.35ng/ml-11.02ng/ml）比 4.78ng/ml（1.06ng/ml-7.6ng/ml），p=0.019]。Kaplan-Meier 曲线显示，抵抗素升高的患者从 DU 中获得的无复发生存率明显降低（p=0.002）。在多变量分析中，抵抗素与新发 DU 相关。血清抵抗素水平升高是 SSc 中新发 DU 的预测标志物。
