Liu Y-P, Li L
Department of Medicine, The second hospital of Shandong University, Jinan, 250033, China.
Department of Thoracic Surgery, The Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, 250031, China.
Cell Mol Biol (Noisy-le-grand). 2017 Sep 30;63(9):59-63. doi: 10.14715/cmb/2017.63.9.11.
Many studies have analyzed the association between between GSTT1 polymorphism and esophageal cancer, however, the results remained inconclusive. We therefore performed an updated meta-analysis based on Chinese individuals. PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure and Chinese Biology Medicine were searched up to December 2016. An OR with the corresponding 95% CI was used to assess the strength of the association. This meta-analysis included 12 studieswith 1246 cases and 1863 controls. Overall, GSTT1 null genotype was associated with an increased esophageal cancer risk when all studies in Chinese populations pooled into this meta-analysis. In stratified studies with geographical location, significantly increased risk was found in North China (OR = 1.45, 95%CI: 1.11-1.91) and in studies with population-based control (OR = 1.29, 95%CI: 1.07-1.55). This study suggested that GSTT1 null genotype may be potential biomarkers for esophageal cancer in China, especially in North China. Studies with larger sample sizes and wider spectrum of populations are warranted to verify this finding.
许多研究分析了谷胱甘肽硫转移酶T1（GSTT1）基因多态性与食管癌之间的关联，然而，结果仍无定论。因此，我们基于中国人群进行了一项更新的荟萃分析。检索了截至2016年12月的PubMed、Springer Link、Ovid、中国万方数据知识服务平台、中国知网和中国生物医学数据库。采用比值比（OR）及相应的95%置信区间（CI）评估关联强度。该荟萃分析纳入了12项研究，共1246例病例和1863例对照。总体而言，当将所有中国人群的研究纳入该荟萃分析时，GSTT1基因缺失型与食管癌风险增加相关。在按地理位置分层的研究中，发现中国北方风险显著增加（OR = 1.45，95%CI：1.11 - 1.91），在基于人群对照的研究中也有增加（OR = 1.29，95%CI：1.07 - 1.55）。本研究表明，GSTT1基因缺失型可能是中国食管癌的潜在生物标志物, 尤其是在中国北方。需要开展样本量更大、人群范围更广的研究来验证这一发现。
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