Jin Bin, Dong Pin, Li Keyong, Shen Bin, Xie Jin
Department of Otolaryngology and Head and Neck Surgery, Affiliated First People's Hospital of Shanghai Jiaotong University, Shanghai, 200080, China.
Tumour Biol. 2014 Jan;35(1):345-9. doi: 10.1007/s13277-013-1047-x. Epub 2013 Aug 16.
Glutathione S-transferase T1 (GSTT1) null genotype has been proven to be associated with risks of many cancers. There were also many studies assessing on the association between GSTT1 null genotype and nasopharyngeal carcinoma risk in Chinese, but the findings from those studies were inconsistent. We performed a meta-analysis to provide a more precise assessment on the effect of GSTT1 null genotype on nasopharyngeal carcinoma risk. The PubMed and Wanfang databases were searched to identify eligible case-control studies on the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese. The pooled odds ratios (OR) with corresponding 95% confidence intervals (95% CI) were used to assess the association. Eight case-control studies with a total of 3,702 individuals were finally included in the meta-analysis. Meta-analysis of a total of eight studies showed that GSTT1 null genotype was significantly associated with increased risk of nasopharyngeal carcinoma in Chinese (OR = 2.27; 95% CI 1.41-3.67; P = 0.001). The finding from cumulative meta-analysis showed that there was a trend of more obvious association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese as data accumulated by publication year. Therefore, the GSTT1 null genotype is significantly associated with increased risk of nasopharyngeal carcinoma in Chinese.
谷胱甘肽S-转移酶T1（GSTT1）无效基因型已被证明与多种癌症的风险相关。也有许多研究评估了GSTT1无效基因型与中国人群鼻咽癌风险之间的关联，但这些研究的结果并不一致。我们进行了一项荟萃分析，以更精确地评估GSTT1无效基因型对鼻咽癌风险的影响。检索了PubMed和万方数据库，以确定关于GSTT1无效基因型与中国人群鼻咽癌风险之间关联的符合条件的病例对照研究。采用合并比值比（OR）及相应的95%置信区间（95%CI）来评估这种关联。最终，共有8项病例对照研究、3702名个体被纳入荟萃分析。对总共8项研究的荟萃分析表明，GSTT1无效基因型与中国人群鼻咽癌风险增加显著相关（OR = 2.27；95%CI 1.41 - 3.67；P = 0.001）。累积荟萃分析的结果表明，随着按发表年份积累的数据增多，GSTT1无效基因型与中国人群鼻咽癌风险之间的关联有更明显的趋势。因此，GSTT1无效基因型与中国人群鼻咽癌风险增加显著相关。
