Xue Chen-Xin, He Xiang-Ming, Zou De-Hong
Clin Lab. 2016 Nov 1;62(11):2277-2284. doi: 10.7754/Clin.Lab.2016.160333.
Published data on the association between present/null polymorphism of glutathione S-transferase M1 (GSTM1) and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis in the Chinese population was performed.
PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between the GSTM1 present/ null polymorphism and breast cancer risk.
A total of 17 studies including 5323 breast cancer cases and 7196 controls were involved in this meta-analysis. Overall, a significant association (OR = 1.28, 95%CI: 1.09 - 1.51) was found between the null GSTM1 and breast cancer risk when all studies in Chinese population were pooled into the meta-analysis. In subgroup analyses stratified by geographic areas and source of controls, the same results were observed in mainland China (OR = 1.42, 95% CI = 1.12 - 1.81) and hospital-based studies (OR = 1.55, 95% CI = 1.20 - 2.00).
This meta-analysis suggests that the GSTM1 null genotype is a low-penetrant risk factor for developing breast cancer in the Chinese population.
关于谷胱甘肽S-转移酶M1（GSTM1）的现患/缺失多态性与乳腺癌风险之间关联的已发表数据尚无定论。为了更精确地估计这种关系，在中国人群中进行了一项荟萃分析。
检索了PubMed、Springer Link、Ovid、中国万方数据知识服务平台、中国知网（CNKI）和中国生物医学文献数据库（CBM）。采用带有95%置信区间（CI）的粗比值比（OR）来评估GSTM1现患/缺失多态性与乳腺癌风险之间关联的强度。
本荟萃分析共纳入17项研究，包括5323例乳腺癌病例和7196例对照。总体而言，当将所有中国人群的研究汇总到荟萃分析中时，发现GSTM1缺失与乳腺癌风险之间存在显著关联（OR = 1.28，95%CI：1.09 - 1.51）。在按地理区域和对照来源分层的亚组分析中，在中国大陆（OR = 1.42，95%CI = 1.12 - 1.81）和基于医院的研究（OR = 1.55，95%CI = 1.20 - 2.00）中观察到相同的结果。
这项荟萃分析表明，GSTM1缺失基因型是中国人群患乳腺癌的一个低外显率风险因素。
