Rockwell E, Lam R W, Zisook S
Department of Psychiatry, University of California, San Diego.
Psychiatr Clin North Am. 1988 Mar;11(1):215-33.
This article reviews the literature on antidepressant drug trials conducted in elderly populations. Only 27 studies of cyclic antidepressants, monoamine oxidase inhibitors (MAOIs), and psychostimulants deal specifically with subjects that were over age 60. Methodologic problems were found in many studies, including lack of diagnostic criteria and inadequate controlling for cognitive impairment, concurrent medical illnesses, and nonpsychotropic medications. Most studies compared second-generation antidepressants against placebo or tricyclic antidepressants (TCAs). Antidepressant drugs are effective treatments for geriatric depression, and limiting side effects are comparable with those seen in younger populations.
本文综述了针对老年人群进行的抗抑郁药物试验的相关文献。仅有27项关于环性抗抑郁药、单胺氧化酶抑制剂（MAOIs）和精神兴奋剂的研究专门针对60岁以上的受试者。许多研究中发现了方法学问题，包括缺乏诊断标准以及对认知障碍、并发内科疾病和非精神类药物的控制不足。大多数研究将第二代抗抑郁药与安慰剂或三环类抗抑郁药（TCAs）进行了比较。抗抑郁药物是老年抑郁症的有效治疗方法，其限制性副作用与年轻人群中所见的副作用相当。
