Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.
Molecules. 2017 Oct 5;22(10):1664. doi: 10.3390/molecules22101664.
Antioxidants are suggested to decrease risk of type 2 diabetes (T2D) by preventing progressive impairment of pancreatic β-cell and endothelial function. This study was aimed to investigate the association between dietary antioxidants and risk of T2D in Korean adults based on a national representative data. A total of 24,377 adults (19-74 years) who completed one-day 24 h dietary recall and health examination were included. Dietary antioxidant intakes including α-carotene (p < 0.0001), lycopene (p = 0.0107), flavan-3-ols (p < 0.0001), and proanthocyanidins (p = 0.0075) were significantly higher in non-diabetic subjects than in diabetic subjects. After adjusting for confounding variables, the highest quartile group of α-carotene intake was associated with a 48% reduced risk of T2D in men (OR: 0.52, 95% CI: 0.34-0.80, p for trend = 0.0037) and a 39% reduced risk in women (OR: 0.61, 95% CI: 0.38-0.996, p for trend = 0.0377) compared to the lowest quartile group. Men in the highest quartile of β-carotene intake showed lower risk of T2D (OR: 0.64, 95% CI: 0.42-0.97), but no significant decreasing trend. However, the intakes of total carotenoids and other antioxidants showed no significant association with the risk of T2D. These findings suggest that a further comprehensive approach which considers overall dietary pattern is required.
抗氧化剂被认为可以通过防止胰腺β细胞和内皮功能的进行性损伤来降低 2 型糖尿病（T2D）的风险。本研究旨在基于全国代表性数据，调查韩国成年人饮食抗氧化剂与 T2D 风险之间的关联。共纳入了 24377 名完成了一天 24 小时膳食回忆和健康检查的成年人（19-74 岁）。与糖尿病患者相比，非糖尿病患者的饮食抗氧化剂摄入量（包括 α-胡萝卜素（p < 0.0001）、番茄红素（p = 0.0107）、黄烷-3-醇（p < 0.0001）和原花青素（p = 0.0075））显著更高。在调整混杂变量后，男性中α-胡萝卜素摄入量最高四分位数组与 T2D 风险降低 48%相关（OR：0.52，95%CI：0.34-0.80，p 趋势 = 0.0037），女性中与 T2D 风险降低 39%相关（OR：0.61，95%CI：0.38-0.996，p 趋势 = 0.0377），与最低四分位数组相比。β-胡萝卜素摄入量最高四分位数组的男性患 T2D 的风险较低（OR：0.64，95%CI：0.42-0.97），但无显著下降趋势。然而，总类胡萝卜素和其他抗氧化剂的摄入量与 T2D 的风险没有显著关联。这些发现表明，需要进一步采用综合方法考虑整体饮食模式。
