Do Sung-Im, Kim Hyun-Soo, Kim Kyungeun, Lee Hyunjoo, Do In-Gu, Kim Dong-Hoon, Chae Seoung Wan, Sohn Jin Hee
Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Anticancer Res. 2017 Oct;37(10):5399-5405. doi: 10.21873/anticanres.11967.
BACKGROUND/AIM: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear.
Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples.
Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue. Sphingosine kinase 1 was observed in the cytoplasm of tumor cells. Thirty-four (30.9%) of 110 papillary thyroid carcinomas exhibited high sphingosine kinase 1 expression, that was significantly associated with tumor multiplicity (p=0.004), extrathyroidal extension (p=0.013), presence of lymph node metastasis (p<0.001), and number of metastatic lymph nodes (p=0.042). In addition, high sphingosine kinase 1 expression was the only independent predictor of lymph node metastasis (p<0.001).
Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.
背景/目的：鞘脂代谢产物正成为癌症中的关键信号分子。鞘氨醇激酶1在许多不同类型的人类恶性肿瘤中上调，并在癌症发展和进展中起关键作用。鞘氨醇激酶1作为甲状腺癌预测生物标志物的效用仍不清楚。
采用免疫组织化学染色法评估110例福尔马林固定、石蜡包埋的甲状腺乳头状癌组织样本中鞘氨醇激酶1的表达。
甲状腺乳头状癌组织中鞘氨醇激酶1的表达显著高于结节性甲状腺肿（p<0.001）或正常甲状腺组织（p<0.001）。在肿瘤细胞的细胞质中观察到鞘氨醇激酶1。110例甲状腺乳头状癌中有34例（30.9%）表现出高鞘氨醇激酶1表达，这与肿瘤多灶性（p=0.004）、甲状腺外侵犯（p=0.013）、淋巴结转移的存在（p<0.001）以及转移淋巴结数量（p=0.042）显著相关。此外，高鞘氨醇激酶1表达是淋巴结转移的唯一独立预测因子（p<0.001）。
鞘氨醇激酶1参与甲状腺乳头状癌的发生和进展，并可作为预测淋巴结转移的潜在生物标志物。
