碳离子放射治疗对妇科癌症淋巴结复发进行再照射的临床影响
Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers.
作者信息
Shiba Shintaro, Okonogi Noriyuki, Kato Shingo, Wakatsuki Masaru, Kobayashi Daijiro, Kiyohara Hiroki, Ohno Tatsuya, Karasawa Kumiko, Nakano Takashi, Kamada Tadashi
机构信息
Hospital, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Japan.
出版信息
Anticancer Res. 2017 Oct;37(10):5577-5583. doi: 10.21873/anticanres.11991.
BACKGROUND/AIM: To evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy.
PATIENTS AND METHODS
Data regarding patients with unresectable and isolated recurrent lymph node from gynecological cancer after definitive radiotherapy were analyzed. Total dose of C-ion RT was 48-57.6 Gy (RBE) in 12 or 16 fractions.
RESULTS
Sixteen patients received re-irradiation by C-ion RT were analyzed. Median follow-up was 37 months. Median tumor size was 27 mm. None developed Grade 1 or higher acute toxicities and Grade 3 or higher late toxicities. The 3-year overall survival, local control and disease-free survival rates after C-ion RT were 74%, 94% and 55%, respectively.
CONCLUSION
Re-irradiation with C-ion RT for lymph node recurrence of gynecological cancers after definitive radiotherapy can be safe and effective. This result suggested that C-ion RT could be a curative treatment option for conventionally difficult-to-cure patients.
背景/目的：评估碳离子放疗（C离子放疗）对妇科癌症根治性放疗后淋巴结复发进行再照射的安全性和有效性。
患者与方法
分析了根治性放疗后妇科癌症不可切除且孤立性复发性淋巴结患者的数据。C离子放疗的总剂量为48 - 57.6 Gy（相对生物效应），分12或16次照射。
结果
分析了16例接受C离子放疗再照射的患者。中位随访时间为37个月。中位肿瘤大小为27毫米。无一例发生1级或更高级别的急性毒性反应以及3级或更高级别的晚期毒性反应。C离子放疗后3年总生存率、局部控制率和无病生存率分别为74%、94%和55%。
结论
C离子放疗对妇科癌症根治性放疗后淋巴结复发进行再照射可能是安全有效的。这一结果表明，C离子放疗对于传统上难以治愈的患者可能是一种根治性治疗选择。
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