食管癌根治性切除术后孤立淋巴结复发的挽救性碳离子放疗
Salvage Carbon-ion Radiotherapy for Isolated Lymph Node Recurrence Following Curative Resection of Esophageal Cancer.
作者信息
Isozaki Yuka, Yasuda Shigeo, Akutsu Yasunori, Shimada Hideaki, Okazumi Shinichi, Nabeya Yoshihiro, Hoshino Isamu, Murakami Kentaro, Ebner Daniel K, Tsuji Hiroshi, Kamada Tadashi, Yamada Shigeru, Matsubara Hisahiro
机构信息
Hospital of the National Institute of Radiological Science, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
Hospital of the National Institute of Radiological Science, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
出版信息
Anticancer Res. 2018 Nov;38(11):6453-6458. doi: 10.21873/anticanres.13007.
AIM
Evaluation of the therapeutic efficacy of carbon-ion radiation therapy for isolated lymph node recurrence following curative resection of esophageal cancer.
MATERIALS AND METHODS
Ten cases with lymph node recurrence after esophageal cancer surgery were treated with carbon-ion radiation therapy. A total of 48.0 Gy [relative biologic effectiveness (RBE)] was delivered over 3 weeks with a daily dose of 4.0 Gy (RBE).
RESULTS
The median follow-up duration was 27.1 months (range=3-92.0 months) after carbon-ion radiation therapy. The local control rates at 2, 3 and 5 years were 92.4%. The overall survival rates at 2, 3 and 5 years were 70.0%, 58.3% and 21.9%. The median survival period was 45.3 months after carbon-ion radiation therapy. There were no toxicities of grade 3 or higher.
CONCLUSION
Carbon-ion radiation therapy may be a safe and effective treatment option for isolated lymph node recurrence after radical surgery for esophageal cancer.
目的
评估碳离子放射治疗对食管癌根治性切除术后孤立性淋巴结复发的治疗效果。
材料与方法
10例食管癌术后淋巴结复发患者接受碳离子放射治疗。3周内共给予48.0 Gy[相对生物效应（RBE）]，每日剂量为4.0 Gy（RBE）。
结果
碳离子放射治疗后中位随访时间为27.1个月（范围=3 - 92.0个月）。2年、3年和5年的局部控制率为92.4%。2年、3年和5年的总生存率分别为70.0%、58.3%和21.9%。碳离子放射治疗后的中位生存期为45.3个月。无3级或更高等级的毒性反应。
结论
碳离子放射治疗可能是食管癌根治术后孤立性淋巴结复发的一种安全有效的治疗选择。
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