食管癌孤立性骨骼肌转移的放化疗：病例报告及文献简要综述

Chemoradiotherapy for Solitary Skeletal Muscle Metastasis from Oesophageal Cancer: Case Report and Brief Literature Review.

作者信息

Fujimoto Yoshiaki, Nakashima Yuichiro, Sasaki Shun, Jogo Tomoko, Hirose Kosuke, Edahiro Keitaro, Korehisa Shotaro, Taniguchi Daisuke, Kudou Kensuke, Nakaji Y U, Nakanishi Ryota, Ando Koji, Saeki Hiroshi, Oki Eiji, Fujiwara Minako, Oda Yoshinao, Maehara Yoshihiko

机构信息

Department of Surgery and Science, Graduate School of Medical Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.

Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Anticancer Res. 2017 Oct;37(10):5687-5691. doi: 10.21873/anticanres.12005.

DOI:10.21873/anticanres.12005

PMID:28982887

Abstract

BACKGROUND

The incidence of skeletal muscle metastasis from oesophageal cancer is very low, and the treatment strategy has not been established.

CASE REPORT

A 77-year-old man underwent oesophagectomy following neoadjuvant chemotherapy for oesophageal squamous cell carcinoma (CT-pT3 N0 M0, CT-pStage II). Fourteen months after surgery, he became aware of a subcutaneous tumour in his left forearm. Computed tomography and fluorodeoxyglucose positron-emission tomography revealed a 65×75 mm intramuscular nodular lesion with a standardized uptake value of 8.5. Further examination by biopsy strongly suggested this was a solitary metastasis from oesophageal cancer. The patient received chemoradiotherapy with two cycles of 5-fluorouracil combined with cisplatin and radiation. Clinical complete response was confirmed by imaging 7 months after chemoradiation and no recurrence has occurred at 20 months since chemoradiation.

CONCLUSION

Radiotherapy or chemoradiotherapy can be an alternative locoregional therapy to surgery for solitary skeletal muscle metastasis.

摘要

背景

食管癌发生骨骼肌转移的发生率非常低，且治疗策略尚未确立。

病例报告

一名77岁男性在接受新辅助化疗后接受了食管癌切除术，病理分期为食管鳞状细胞癌（CT-pT3 N0 M0，CT-pII期）。术后14个月，他发现左前臂有一个皮下肿瘤。计算机断层扫描和氟脱氧葡萄糖正电子发射断层扫描显示一个65×75mm的肌内结节性病变，标准化摄取值为8.5。活检进一步检查强烈提示这是食管癌的孤立转移灶。该患者接受了两个周期的5-氟尿嘧啶联合顺铂化疗及放疗的放化疗。放化疗7个月后影像学检查确认临床完全缓解，自放化疗后20个月未出现复发。