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单一位外科医生行小梁切开联合小梁切除术治疗先天性青光眼的长期疗效观察。

Long-term outcome of combined trabeculotomy-trabeculectomy by a single surgeon in patients with primary congenital glaucoma.

机构信息

Glaucoma Clinic New Delhi, New Delhi India.

SK Glaucoma Care Foundation, New Delhi India.

出版信息

Eye (Lond). 2018 Feb;32(2):426-432. doi: 10.1038/eye.2017.207. Epub 2017 Oct 6.

Abstract

PurposeAssess long-term outcome of combined trabeculotomy-trabeculectomy (CTT) in primary congenital glaucoma (PCG).MethodsData of PCG patients treated with CTT by a single surgeon between 1976 and 1993 were reviewed for reduction in intraocular pressure (IOP), visual acuities, surgical success rates, and need for repeat surgeries at last follow-up (FU). At the last FU, IOP<21 mm Hg without any topical antiglaucoma medication (TAM) was complete success and with 1-2 TAMs was qualified success. IOP reduction ≥30% without any TAM was modified complete success and with 1-2 TAMs was modified qualified success. IOP>21 mm Hg, IOP reduction <30%, or use of >2 TAM at last FU, or need for additional surgery was considered as failure.ResultsTwo hundred thirty eyes of 121 patients had been followed up for 21.5-38 years (mean 28.87±2.77 years). Eyes that were pthisical (3), had immeasurable IOP (2), or IOP<6 mm Hg (3) were excluded from the success analysis. At last FU, mean IOP reduction was 22.71±11.28 mm Hg and TAM score was 1.71 (0-4). Complete success was achieved in 14 (6.3%), modified complete success in 14 (6.3%), qualified success in 148 (66.7%), and modified qualified success in 140 (63.1%). Success probability was 95% till 25 years and 92, 90, 85, 79 and 68% at 26, 27, 28, 29, and 30 years, respectively. Severe visual impairment or functional blindness was found in only 13 (10.7%) patients.ConclusionCTT shows long-term success in PCG patients. All patients must be monitored for IOP control to avoid need for repeat surgeries.

摘要

目的评估原发性先天性青光眼(PCG)患者联合小梁切开术-小梁切除术(CTT)的长期疗效。

方法回顾性分析 1976 年至 1993 年间由同一位外科医生行 CTT 治疗的 PCG 患者的临床资料,包括眼压(IOP)降低、视力、手术成功率以及末次随访(FU)时是否需要再次手术。末次 FU 时,无需任何局部抗青光眼药物(TAM)眼压<21mmHg 为完全成功,使用 1-2 种 TAMs 为合格成功。眼压降低≥30%而无需任何 TAMs 为改良完全成功,使用 1-2 种 TAMs 为改良合格成功。末次 FU 时眼压>21mmHg、眼压降低<30%、或使用>2 种 TAMs 或需要再次手术则认为手术失败。

结果121 例患者的 230 只眼接受了 21.5-38 年(平均 28.87±2.77 年)的随访。对已萎缩(3 只眼)、IOP 无法测量(2 只眼)或 IOP<6mmHg(3 只眼)的眼排除在成功分析之外。末次 FU 时,平均眼压降低 22.71±11.28mmHg,TAM 评分为 1.71(0-4)。14 只眼(6.3%)获得完全成功,14 只眼(6.3%)获得改良完全成功,148 只眼(66.7%)获得合格成功,140 只眼(63.1%)获得改良合格成功。25 年内成功率为 95%,26、27、28、29 和 30 年时成功率分别为 92%、90%、85%、79%和 68%。仅 13 例(10.7%)患者视力严重受损或失明。

结论CTT 治疗 PCG 患者可获得长期疗效。所有患者均需监测眼压控制情况,以避免需要再次手术。

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