Carrera A C, Rincón M, De Landázuri M O, López-Botet M
Seccion de Immunología, Hospital de la Princesa, Madrid, Spain.
Eur J Immunol. 1988 Jun;18(6):961-4. doi: 10.1002/eji.1830180620.
The human T lymphocyte-specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP comparable to that induced by reagents which activate adenylate cyclase. These results indicate that there is a relationship between the CD2 membrane molecule and the adenylate cyclase system.
调节T细胞活化的人T淋巴细胞特异性CD2（T11）分子能够介导细胞内cAMP增加。针对CD2分子不同表位的单克隆抗体，无论是诱导还是抑制T细胞增殖，都能引发与激活腺苷酸环化酶的试剂所诱导的cAMP增加相当的情况。这些结果表明CD2膜分子与腺苷酸环化酶系统之间存在关联。
