Department of Pediatrics, Stanford University School of Medicine, 780 Welch Road, MC 5776, Palo Alto, CA, 94304, USA.
Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
J Behav Med. 2018 Apr;41(2):243-252. doi: 10.1007/s10865-017-9892-5. Epub 2017 Oct 5.
Cancer patients have high rates of persistent and disabling symptoms. Evidence suggests that social constraints (e.g., avoidance and criticism) negatively impact symptoms, but pathways linking these variables have yet to be identified. This study examined whether cancer-related loneliness (i.e., feeling socially disconnected related to having cancer) mediated the relationships between social constraints and symptoms (i.e., pain interference, fatigue, sleep disturbance, and cognitive complaints) in patients with various cancers (N = 182). Patients (51% female, mean age = 59) were recruited from the Indiana Cancer Registry and completed questionnaires assessing social constraints, cancer-related loneliness, and symptoms. Structural equation modeling was used to evaluate the hypothesized relationships among variables. The model demonstrated good fit. Consistent with our hypothesis, cancer-related loneliness mediated the relationships between social constraints and each symptom. Findings suggest that addressing cancer-related loneliness in symptom management interventions may mitigate the negative impact of social constraints on outcomes.
癌症患者存在较高比例的持续性和致残性症状。有证据表明,社会约束(例如回避和批评)会对症状产生负面影响,但这些变量之间的关联途径尚未确定。本研究旨在探讨癌症相关孤独感(即与癌症相关的社会隔离感)是否在各种癌症患者(N=182)的社会约束与症状(即疼痛干扰、疲劳、睡眠障碍和认知抱怨)之间的关系中起中介作用。患者(51%为女性,平均年龄=59 岁)是从印第安纳癌症登记处招募的,他们完成了评估社会约束、癌症相关孤独感和症状的问卷。结构方程模型用于评估变量之间的假设关系。模型显示出良好的拟合度。与我们的假设一致,癌症相关孤独感在社会约束与每种症状之间的关系中起中介作用。研究结果表明,在症状管理干预中解决癌症相关孤独感可能会减轻社会约束对结局的负面影响。