Synthesis and beta-adrenergic blocking activity of oxipropanolamines of 3,4-dihydro-3-oxo-2H(1,4)benzothiazine.
作者信息
Cecchetti V, Fravolini A, Fringuelli R, Schiaffella F, Mascellani G, Pagella P G, Rugarli P L
机构信息
Istituto di Chimica Farmaceutica e Tecnica Farmaceutica-Università di Perugia, Italy.
出版信息
Farmaco Sci. 1987 Jan;42(1):61-75.
PMID:2898382
Abstract
The synthesis of a series of oxypropanolamines of 3,4-dihydro-3-oxo-2H(1,4)benzothiazine is reported. Some of these compounds proved more potent than propranolol and carteolol as beta-adrenergic blocking agents in in vitro tests. The 8-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydro-3-oxo-2H(1,4) benzothiazine fumarate (XVI a), which gave better results, confirmed its remarkable activity in in vivo tests.
摘要
Zotero 插件