某些1-烷基氨基-3-(2'-甲氧基-4'-二乙基氨基甲酰基苯氧基)丙-2-醇的合成及药理活性
Synthesis and pharmacological activity of some 1-alkylamino-3-(2'-methoxy-4'-diethylcarbamoyl-phenoxy)propan-2-ols.
作者信息
Monforte P, Basile M, Previtera T, Larizza A, Marmo E, De Gennaro G, Montinaro C, Filippelli W, Montanaro C S, Marfella A, Larizza D
出版信息
Farmaco Sci. 1983 Mar;28(3):173-86.
PMID:6133779
Abstract
The synthesis and pharmacological properties of some 1-alkylamino-3-(2'-methoxy-4'-diethylcarbamoylphenoxy)propan-2-ols, related to beta-adrenergic drugs, are described. The above compounds were found to possess beta 1 and beta 2-adrenolytic activity associated with local anesthetic and antiarrhythmic activities, which are clearly inferior to those of propranolol.
摘要
本文描述了一些与β-肾上腺素能药物相关的1-烷基氨基-3-(2'-甲氧基-4'-二乙氨基甲酰苯氧基)丙-2-醇的合成及其药理性质。发现上述化合物具有β1和β2肾上腺素能阻断活性，并伴有局部麻醉和抗心律失常活性，但其活性明显低于普萘洛尔。
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